Reaction Details |
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Target | Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide |
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Ligand | BDBM572192 |
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Substrate/Competitor | n/a |
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Meas. Tech. | MCL-1/Noxa BH3 Peptide (MCL-1 Assay) |
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IC50 | 1.30±n/a nM |
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Citation | Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Macrocyclic chlorine substituted indole derivatives US Patent US11478451 Publication Date 10/25/2022 |
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More Info.: | Get all data from this article, Assay Method |
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Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide |
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Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide |
Synonyms: | MCL-1/Noxa BH3 Peptide |
Type: | Protein |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 3 components. |
Component 1 |
Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321] |
Synonyms: | BCL2L3 | MCL1 | MCL1_HUMAN |
Type: | n/a |
Mol. Mass.: | 17056.39 |
Organism: | Homo sapiens (Human) |
Description: | Q07820[173-321] |
Residue: | 149 |
Sequence: | ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGML
RKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAE
SITDVLVRTKRDWLVKQRGWDGFVEFFHV
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Component 2 |
Name: | Maltose/maltodextrin import ATP-binding protein MalK |
Synonyms: | MALK_ECOLI | malK |
Type: | Protein |
Mol. Mass.: | 40990.98 |
Organism: | n/a |
Description: | P68187 |
Residue: | 371 |
Sequence: | MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDL
FIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEV
LQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLH
KRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMN
FLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVIL
EGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGT
ACRRLHKEPGV
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Component 3 |
Name: | Phorbol-12-myristate-13-acetate-induced protein 1 [17-23,25-42,C24V] |
Synonyms: | APR_HUMAN | Immediate-early-response protein APR | NOXA | PMA-induced protein 1 | PMAIP1 | Protein Noxa |
Type: | Protein |
Mol. Mass.: | 3072.54 |
Organism: | Human |
Description: | Biotin-PEG2-PEG2-PAELEVE-Nva-ATQLRRFGDKLNFRQKLL-amide |
Residue: | 26 |
Sequence: | PAELEVEVATQLRRFGDKLNFRQKLL
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BDBM572192 |
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n/a |
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Name | BDBM572192 |
Synonyms: | (rac)-4-chloro-3-ethyl-14-methyl-1-[2-(morpholin-4-yl)ethyl]-7-{3-[(naphthalen-1-yl)oxy]propyl}-10,11,12,13,14,15-hexahydro-1H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid | US11447504, Example 45 | US11447504, Example 46 | US11447504, Example 47 | US11478451, Example 47 |
Type | Small organic molecule |
Emp. Form. | C39H46ClN5O4 |
Mol. Mass. | 684.267 |
SMILES | CCc1nn(CCN2CCOCC2)c2CN(C)CCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 |
Structure |
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