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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | G protein-activated inward rectifier potassium channel 1/4 | ||
| Ligand | BDBM585718 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | IonWorks Quattro system | ||
| IC50 | 15.0±n/a nM | ||
| Citation |  Barbe, G; Bebernitz, GR; Geng, S; Gulgeze Efthymiou, HB; Liao, L; Ma, F; Mo, R; Parker, DT; Peng, Y; Peukert, S; Smith, N; Yamada, K; Yasoshima, K Naphthyridinone derivatives and their use in the treatment of arrhythmia US Patent US11530213 Publication Date 12/20/2022 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| G protein-activated inward rectifier potassium channel 1/4 | |||
| Name: | G protein-activated inward rectifier potassium channel 1/4 | ||
| Synonyms: | GIRK1/4 channels | Kir3.1/Kir3.4 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | n/a | ||
| Description: | n/a | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | G protein-activated inward rectifier potassium channel 1 | ||
| Synonyms: | GIRK-1 | GIRK1 | Inward rectifier K(+) channel Kir3.1 | KCNJ3 | KCNJ3_HUMAN | Potassium channel, inwardly rectifying subfamily J member 3 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 56610.74 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_107915 | ||
| Residue: | 501 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | G protein-activated inward rectifier potassium channel 4 | ||
| Synonyms: | CIR | Cardiac inward rectifier | GIRK-4 | GIRK4 | Heart KATP channel | IRK-4 | Inward rectifier K(+) channel Kir3.4 | KATP-1 | KCNJ5 | KCNJ5_HUMAN | Potassium channel, inwardly rectifying subfamily J member 5 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 47658.06 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_107914 | ||
| Residue: | 419 | ||
| Sequence: |
| ||
| BDBM585718 | |||
| n/a | |||
| Name | BDBM585718 | ||
| Synonyms: | (S)-8-chloro-1-(2,6- dichlorophenyl)-5-((2,3- dihydroxypropyl)amino)-2-methyl- 1,6-naphthyridin-4(1H)-one | US11530213, Example 39 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H16Cl3N3O3 | ||
| Mol. Mass. | 428.697 | ||
| SMILES | Cc1cc(=O)c2c(NC[C@H](O)CO)ncc(Cl)c2n1-c1c(Cl)cccc1Cl |r,wD:9.9,(4.67,-.14,;3.33,-.91,;3.33,-2.45,;2,-3.22,;2,-4.76,;.67,-2.45,;-.67,-3.22,;-.67,-4.76,;-2,-5.53,;-3.33,-4.76,;-4.67,-5.53,;-3.33,-3.22,;-4.67,-2.45,;-2,-2.45,;-2,-.91,;-.67,-.14,;-.67,1.4,;.67,-.91,;2,-.14,;2,2.45,;.67,3.22,;-.67,2.45,;.67,4.76,;2,5.53,;3.33,4.76,;3.33,3.22,;4.67,2.45,)| | ||
| Structure | 
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