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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | G protein-activated inward rectifier potassium channel 1/4 | ||
| Ligand | BDBM585720 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | IonWorks Quattro system | ||
| IC50 | 28.0±n/a nM | ||
| Citation |  Barbe, G; Bebernitz, GR; Geng, S; Gulgeze Efthymiou, HB; Liao, L; Ma, F; Mo, R; Parker, DT; Peng, Y; Peukert, S; Smith, N; Yamada, K; Yasoshima, K Naphthyridinone derivatives and their use in the treatment of arrhythmia US Patent US11530213 Publication Date 12/20/2022 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| G protein-activated inward rectifier potassium channel 1/4 | |||
| Name: | G protein-activated inward rectifier potassium channel 1/4 | ||
| Synonyms: | GIRK1/4 channels | Kir3.1/Kir3.4 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | n/a | ||
| Description: | n/a | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | G protein-activated inward rectifier potassium channel 1 | ||
| Synonyms: | GIRK-1 | GIRK1 | Inward rectifier K(+) channel Kir3.1 | KCNJ3 | KCNJ3_HUMAN | Potassium channel, inwardly rectifying subfamily J member 3 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 56610.74 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_107915 | ||
| Residue: | 501 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | G protein-activated inward rectifier potassium channel 4 | ||
| Synonyms: | CIR | Cardiac inward rectifier | GIRK-4 | GIRK4 | Heart KATP channel | IRK-4 | Inward rectifier K(+) channel Kir3.4 | KATP-1 | KCNJ5 | KCNJ5_HUMAN | Potassium channel, inwardly rectifying subfamily J member 5 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 47658.06 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_107914 | ||
| Residue: | 419 | ||
| Sequence: |
| ||
| BDBM585720 | |||
| n/a | |||
| Name | BDBM585720 | ||
| Synonyms: | 8-chloro-1-(2,6-dichlorophenyl)-5- (3-hydroxy-2-(hydroxymethyl)-2- methylpropoxy)-2-methyl-1,6- naphthyridin-4(1H)-one | US11530213, Example 41 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H19Cl3N2O4 | ||
| Mol. Mass. | 457.735 | ||
| SMILES | Cc1cc(=O)c2c(OCC(C)(CO)CO)ncc(Cl)c2n1-c1c(Cl)cccc1Cl |(4.67,2.31,;3.33,1.54,;3.33,,;2,-.77,;2,-2.31,;.67,,;-.67,-.77,;-.67,-2.31,;-2,-3.08,;-2,-4.62,;-.67,-3.85,;-.67,-5.39,;-.67,-6.93,;-3.33,-5.39,;-4.67,-4.62,;-2,,;-2,1.54,;-.67,2.31,;-.67,3.85,;.67,1.54,;2,2.31,;2,3.85,;.67,4.62,;-.67,5.39,;.67,6.16,;2,6.93,;3.33,6.16,;3.33,4.62,;4.67,3.85,)| | ||
| Structure | 
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