Reaction Details |
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Target | G protein-activated inward rectifier potassium channel 1/4 |
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Ligand | BDBM585728 |
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Substrate/Competitor | n/a |
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Meas. Tech. | IonWorks Quattro system |
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IC50 | 42.0±n/a nM |
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Citation | Barbe, G; Bebernitz, GR; Geng, S; Gulgeze Efthymiou, HB; Liao, L; Ma, F; Mo, R; Parker, DT; Peng, Y; Peukert, S; Smith, N; Yamada, K; Yasoshima, K Naphthyridinone derivatives and their use in the treatment of arrhythmia US Patent US11530213 Publication Date 12/20/2022 |
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More Info.: | Get all data from this article, Assay Method |
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G protein-activated inward rectifier potassium channel 1/4 |
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Name: | G protein-activated inward rectifier potassium channel 1/4 |
Synonyms: | GIRK1/4 channels | Kir3.1/Kir3.4 |
Type: | PROTEIN |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | G protein-activated inward rectifier potassium channel 1 |
Synonyms: | GIRK-1 | GIRK1 | Inward rectifier K(+) channel Kir3.1 | KCNJ3 | KCNJ3_HUMAN | Potassium channel, inwardly rectifying subfamily J member 3 |
Type: | PROTEIN |
Mol. Mass.: | 56610.74 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_107915 |
Residue: | 501 |
Sequence: | MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNL
GSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNY
TPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCM
FIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPE
GEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILE
GIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKE
QEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQKITGREDFPKKLLRMS
STTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGG
AARMEGNLPAKLRKMNSDRFT
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Component 2 |
Name: | G protein-activated inward rectifier potassium channel 4 |
Synonyms: | CIR | Cardiac inward rectifier | GIRK-4 | GIRK4 | Heart KATP channel | IRK-4 | Inward rectifier K(+) channel Kir3.4 | KATP-1 | KCNJ5 | KCNJ5_HUMAN | Potassium channel, inwardly rectifying subfamily J member 5 |
Type: | PROTEIN |
Mol. Mass.: | 47658.06 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_107914 |
Residue: | 419 |
Sequence: | MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKC
NVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDH
VGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNA
FMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIK
SRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINQKSPFWEMSQAQLHQEEFE
VVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTP
SCCAKELAEMKREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV
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BDBM585728 |
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n/a |
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Name | BDBM585728 |
Synonyms: | 8-chloro-1-(2,6-dichlorophenyl)-5- ((2-hydroxyethoxy)amino)-2- methyl-1,6-naphthyridin-4(1H)-one | US11530213, Example 49 |
Type | Small organic molecule |
Emp. Form. | C17H14Cl3N3O3 |
Mol. Mass. | 414.67 |
SMILES | Cc1cc(=O)c2c(NOCCO)ncc(Cl)c2n1-c1c(Cl)cccc1Cl |(4,1.84,;2.67,1.07,;2.67,-.47,;1.33,-1.24,;1.33,-2.78,;,-.47,;-1.33,-1.24,;-1.33,-2.78,;-2.67,-3.55,;-2.67,-5.09,;-4,-5.86,;-4,-7.4,;-2.67,-.47,;-2.67,1.07,;-1.33,1.84,;-1.33,3.38,;,1.07,;1.33,1.84,;1.33,4.32,;2.67,5.09,;4,4.32,;2.67,6.63,;1.33,7.4,;,6.63,;,5.09,;-1.33,4.32,)| |
Structure |
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