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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | G protein-activated inward rectifier potassium channel 1/4 | ||
| Ligand | BDBM585734 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | IonWorks Quattro system | ||
| IC50 | 54.0±n/a nM | ||
| Citation |  Barbe, G; Bebernitz, GR; Geng, S; Gulgeze Efthymiou, HB; Liao, L; Ma, F; Mo, R; Parker, DT; Peng, Y; Peukert, S; Smith, N; Yamada, K; Yasoshima, K Naphthyridinone derivatives and their use in the treatment of arrhythmia US Patent US11530213 Publication Date 12/20/2022 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| G protein-activated inward rectifier potassium channel 1/4 | |||
| Name: | G protein-activated inward rectifier potassium channel 1/4 | ||
| Synonyms: | GIRK1/4 channels | Kir3.1/Kir3.4 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | n/a | ||
| Description: | n/a | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | G protein-activated inward rectifier potassium channel 1 | ||
| Synonyms: | GIRK-1 | GIRK1 | Inward rectifier K(+) channel Kir3.1 | KCNJ3 | KCNJ3_HUMAN | Potassium channel, inwardly rectifying subfamily J member 3 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 56610.74 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_107915 | ||
| Residue: | 501 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | G protein-activated inward rectifier potassium channel 4 | ||
| Synonyms: | CIR | Cardiac inward rectifier | GIRK-4 | GIRK4 | Heart KATP channel | IRK-4 | Inward rectifier K(+) channel Kir3.4 | KATP-1 | KCNJ5 | KCNJ5_HUMAN | Potassium channel, inwardly rectifying subfamily J member 5 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 47658.06 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_107914 | ||
| Residue: | 419 | ||
| Sequence: |
| ||
| BDBM585734 | |||
| n/a | |||
| Name | BDBM585734 | ||
| Synonyms: | 3-chloro-2-(8-chloro-2- cyclopropyl-5-(2,3- dihydroxypropoxy)-4-oxo-1,6- naphthyridin-1(4H)-yl)benzonitrile | US11530213, Example 55 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H17Cl2N3O4 | ||
| Mol. Mass. | 446.283 | ||
| SMILES | OCC(O)COc1ncc(Cl)c2n(c(cc(=O)c12)C1CC1)-c1c(Cl)cccc1C#N |(-.87,-5.39,;-2.21,-6.16,;-3.54,-5.39,;-4.87,-6.16,;-3.54,-3.85,;-2.21,-3.08,;-2.21,-1.54,;-3.54,-.77,;-3.54,.77,;-2.21,1.54,;-2.21,3.08,;-.87,.77,;.46,1.54,;1.79,.77,;1.79,-.77,;.46,-1.54,;.46,-3.08,;-.87,-.77,;3.13,1.54,;4.46,.77,;4.46,2.31,;.46,3.08,;-.87,3.85,;-2.21,4.62,;-.87,5.39,;.46,6.16,;1.79,5.39,;1.84,3.82,;3.18,3.05,;4.97,1.82,)| | ||
| Structure | 
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