Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | G protein-activated inward rectifier potassium channel 1/4 | ||
| Ligand | BDBM585736 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | IonWorks Quattro system | ||
| IC50 | 32.0±n/a nM | ||
| Citation |  Barbe, G; Bebernitz, GR; Geng, S; Gulgeze Efthymiou, HB; Liao, L; Ma, F; Mo, R; Parker, DT; Peng, Y; Peukert, S; Smith, N; Yamada, K; Yasoshima, K Naphthyridinone derivatives and their use in the treatment of arrhythmia US Patent US11530213 Publication Date 12/20/2022 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| G protein-activated inward rectifier potassium channel 1/4 | |||
| Name: | G protein-activated inward rectifier potassium channel 1/4 | ||
| Synonyms: | GIRK1/4 channels | Kir3.1/Kir3.4 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | n/a | ||
| Description: | n/a | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | G protein-activated inward rectifier potassium channel 1 | ||
| Synonyms: | GIRK-1 | GIRK1 | Inward rectifier K(+) channel Kir3.1 | KCNJ3 | KCNJ3_HUMAN | Potassium channel, inwardly rectifying subfamily J member 3 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 56610.74 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_107915 | ||
| Residue: | 501 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | G protein-activated inward rectifier potassium channel 4 | ||
| Synonyms: | CIR | Cardiac inward rectifier | GIRK-4 | GIRK4 | Heart KATP channel | IRK-4 | Inward rectifier K(+) channel Kir3.4 | KATP-1 | KCNJ5 | KCNJ5_HUMAN | Potassium channel, inwardly rectifying subfamily J member 5 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 47658.06 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_107914 | ||
| Residue: | 419 | ||
| Sequence: |
| ||
| BDBM585736 | |||
| n/a | |||
| Name | BDBM585736 | ||
| Synonyms: | 8-chloro-1-(2,6-dichlorophenyl)-5- ((2,2-dimethyl-1,3-dioxolan-4- yl)methoxy)-2-(hydroxymethyl)- 1,6-naphthyridin-4(1H)-one | US11530213, Example 57 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H19Cl3N2O5 | ||
| Mol. Mass. | 485.745 | ||
| SMILES | CC1(C)OCC(COc2ncc(Cl)c3n(c(CO)cc(=O)c23)-c2c(Cl)cccc2Cl)O1 |(-2.21,-8.21,;-2.61,-6.72,;-1.12,-7.12,;-4.15,-6.72,;-4.62,-5.26,;-3.38,-4.35,;-3.38,-2.81,;-2.04,-2.04,;-2.04,-.5,;-3.38,.27,;-3.38,1.81,;-2.04,2.58,;-2.04,4.12,;-.71,1.81,;.62,2.58,;1.96,1.81,;3.29,2.58,;4.62,1.81,;1.96,.27,;.62,-.5,;.62,-2.04,;-.71,.27,;.62,5.13,;-.71,5.9,;-2.04,5.13,;-.71,7.44,;.62,8.21,;1.96,7.44,;1.96,5.9,;3.29,5.13,;-2.13,-5.26,)| | ||
| Structure | 
| ||