Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | G protein-activated inward rectifier potassium channel 1/4 | ||
| Ligand | BDBM585742 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | IonWorks Quattro system | ||
| IC50 | 16.0±n/a nM | ||
| Citation |  Barbe, G; Bebernitz, GR; Geng, S; Gulgeze Efthymiou, HB; Liao, L; Ma, F; Mo, R; Parker, DT; Peng, Y; Peukert, S; Smith, N; Yamada, K; Yasoshima, K Naphthyridinone derivatives and their use in the treatment of arrhythmia US Patent US11530213 Publication Date 12/20/2022 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| G protein-activated inward rectifier potassium channel 1/4 | |||
| Name: | G protein-activated inward rectifier potassium channel 1/4 | ||
| Synonyms: | GIRK1/4 channels | Kir3.1/Kir3.4 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | n/a | ||
| Description: | n/a | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | G protein-activated inward rectifier potassium channel 1 | ||
| Synonyms: | GIRK-1 | GIRK1 | Inward rectifier K(+) channel Kir3.1 | KCNJ3 | KCNJ3_HUMAN | Potassium channel, inwardly rectifying subfamily J member 3 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 56610.74 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_107915 | ||
| Residue: | 501 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | G protein-activated inward rectifier potassium channel 4 | ||
| Synonyms: | CIR | Cardiac inward rectifier | GIRK-4 | GIRK4 | Heart KATP channel | IRK-4 | Inward rectifier K(+) channel Kir3.4 | KATP-1 | KCNJ5 | KCNJ5_HUMAN | Potassium channel, inwardly rectifying subfamily J member 5 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 47658.06 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_107914 | ||
| Residue: | 419 | ||
| Sequence: |
| ||
| BDBM585742 | |||
| n/a | |||
| Name | BDBM585742 | ||
| Synonyms: | US11530213, Example 63 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H12Cl3N3O4 | ||
| Mol. Mass. | 440.665 | ||
| SMILES | OCC(O)COc1ncc(Cl)c2n(c(cc(=O)c12)C#N)-c1c(Cl)cccc1Cl |(-4.67,-7.29,;-4.67,-5.75,;-3.33,-4.98,;-2,-5.75,;-3.33,-3.44,;-2,-2.67,;-2,-1.13,;-3.33,-.36,;-3.33,1.18,;-2,1.95,;-2,3.49,;-.67,1.18,;.67,1.95,;2,1.18,;2,-.36,;.67,-1.13,;.67,-2.67,;-.67,-.36,;3.33,1.95,;4.67,2.72,;.67,4.21,;-.67,4.98,;-2,4.21,;-.67,6.52,;.67,7.29,;2,6.52,;2,4.98,;3.33,4.21,)| | ||
| Structure | 
| ||