Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | G protein-activated inward rectifier potassium channel 1/4 | ||
| Ligand | BDBM585745 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | IonWorks Quattro system | ||
| IC50 | 34.0±n/a nM | ||
| Citation |  Barbe, G; Bebernitz, GR; Geng, S; Gulgeze Efthymiou, HB; Liao, L; Ma, F; Mo, R; Parker, DT; Peng, Y; Peukert, S; Smith, N; Yamada, K; Yasoshima, K Naphthyridinone derivatives and their use in the treatment of arrhythmia US Patent US11530213 Publication Date 12/20/2022 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| G protein-activated inward rectifier potassium channel 1/4 | |||
| Name: | G protein-activated inward rectifier potassium channel 1/4 | ||
| Synonyms: | GIRK1/4 channels | Kir3.1/Kir3.4 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | n/a | ||
| Description: | n/a | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | G protein-activated inward rectifier potassium channel 1 | ||
| Synonyms: | GIRK-1 | GIRK1 | Inward rectifier K(+) channel Kir3.1 | KCNJ3 | KCNJ3_HUMAN | Potassium channel, inwardly rectifying subfamily J member 3 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 56610.74 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_107915 | ||
| Residue: | 501 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | G protein-activated inward rectifier potassium channel 4 | ||
| Synonyms: | CIR | Cardiac inward rectifier | GIRK-4 | GIRK4 | Heart KATP channel | IRK-4 | Inward rectifier K(+) channel Kir3.4 | KATP-1 | KCNJ5 | KCNJ5_HUMAN | Potassium channel, inwardly rectifying subfamily J member 5 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 47658.06 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_107914 | ||
| Residue: | 419 | ||
| Sequence: |
| ||
| BDBM585745 | |||
| n/a | |||
| Name | BDBM585745 | ||
| Synonyms: | US11530213, Example 66 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H20Cl2N2O4 | ||
| Mol. Mass. | 423.29 | ||
| SMILES | CCc1cc2n(c(C)cc(=O)c2c(OC[C@@H](O)CO)n1)-c1c(Cl)cccc1Cl |r,wU:15.16,(-10.12,9.44,;-8.79,10.21,;-7.45,9.44,;-6.12,10.21,;-4.79,9.44,;-3.45,10.21,;-2.12,9.44,;-.79,10.21,;-2.12,7.9,;-3.45,7.13,;-3.45,5.59,;-4.79,7.9,;-6.12,7.13,;-6.12,5.59,;-7.45,4.82,;-7.45,3.28,;-6.12,2.51,;-8.79,2.51,;-8.79,.97,;-7.45,7.9,;-3.45,11.95,;-2.12,12.72,;-.79,11.95,;-2.12,14.26,;-3.45,15.03,;-4.79,14.26,;-4.79,12.72,;-6.12,11.95,)| | ||
| Structure | 
| ||