Ki Summary

Reaction Details

Report a problem with these data

Target

Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]

Ligand

BDBM585797

Substrate/Competitor

n/a

Meas. Tech.

Cbl-b Displacement Assay (Cbl-b Inhibition Assay low)

IC50

<1±n/a nM

Citation

Sands, AT; Bence, NF; Zapf, CW; Cohen, F; Wang, C; Cummins, T; Tanaka, H; Shunatona, H; Cardozo, M; Weiss, D; Gosling, J Cyano cyclobutyl compounds for CBL-B inhibition and uses thereof US Patent US11530229 Publication Date 12/20/2022

More Info.:

Get all data from this article, Assay Method

Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]

Name:

Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]

Synonyms:

CBLB | CBLB_HUMAN | E3 ubiquitin-protein ligase CBL-B [36-427] | RNF56

Type:

Enzyme Catalytic Domain

Mol. Mass.:

45487.32

Organism:

Homo sapiens (Human)

Description:

aa 36-427 (sequence in paper SEQ ID No: 1)

Residue:

392

Sequence:

PKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDN
QKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLA
EIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMA
LKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQK
YSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGR
SYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTS
CLTAWQESDGQGCPFCRCEIKGTEPIIVDPFD

BDBM585797

n/a

Name

BDBM585797

Synonyms:

US11530229, Compound 12

Type

Small organic molecule

Emp. Form.

C31H29F5N6O

Mol. Mass.

596.5936

SMILES

Cn1cnnc1C[C@@]1(C[C@@H](C1)C#N)c1cccc(c1)N1Cc2c(cc(CNC3CC4C(C3)C4(F)F)cc2C(F)(F)F)C1=O |r,wU:9.12,wD:7.14,(8.23,-1.35,;6.77,-1.83,;6.29,-3.29,;4.75,-3.29,;4.28,-1.83,;5.52,-.92,;5.52,.62,;6.86,1.39,;7.94,.3,;9.03,1.39,;7.94,2.48,;10.57,1.39,;12.11,1.39,;5.52,2.16,;5.52,3.7,;4.19,4.47,;2.85,3.7,;2.85,2.16,;4.19,1.39,;1.52,1.39,;1.36,-.15,;-.15,-.47,;-.92,.87,;-2.46,.87,;-3.23,-.47,;-4.77,-.47,;-5.54,-1.8,;-7.08,-1.8,;-7.98,-.55,;-9.45,-1.03,;-9.45,-2.57,;-7.98,-3.04,;-10.78,-1.8,;-12.11,-1.03,;-12.11,-2.57,;-2.46,-1.8,;-.92,-1.8,;-.15,-3.13,;-.92,-4.47,;1.39,-3.13,;.62,-4.47,;.11,2.01,;-.21,3.52,)|

Structure