Ki Summary

Reaction Details

Report a problem with these data

Target

Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]

Ligand

BDBM585839

Substrate/Competitor

n/a

Meas. Tech.

Cbl-b Displacement Assay (Cbl-b Inhibition Assay low)

IC50

<1±n/a nM

Citation

Sands, AT; Bence, NF; Zapf, CW; Cohen, F; Wang, C; Cummins, T; Tanaka, H; Shunatona, H; Cardozo, M; Weiss, D; Gosling, J Cyano cyclobutyl compounds for CBL-B inhibition and uses thereof US Patent US11530229 Publication Date 12/20/2022

More Info.:

Get all data from this article, Assay Method

Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]

Name:

Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]

Synonyms:

CBLB | CBLB_HUMAN | E3 ubiquitin-protein ligase CBL-B [36-427] | RNF56

Type:

Enzyme Catalytic Domain

Mol. Mass.:

45487.32

Organism:

Homo sapiens (Human)

Description:

aa 36-427 (sequence in paper SEQ ID No: 1)

Residue:

392

Sequence:

PKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDN
QKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLA
EIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMA
LKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQK
YSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGR
SYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTS
CLTAWQESDGQGCPFCRCEIKGTEPIIVDPFD

BDBM585839

n/a

Name

BDBM585839

Synonyms:

US11530229, Compound 54

Type

Small organic molecule

Emp. Form.

C32H39N7O

Mol. Mass.

537.6984

SMILES

C[C@H]1C[C@@H](C)CN(Cc2cc(nc(c2)C(=O)Nc2cccc(c2)[C@@]2(Cc3nncn3C)C[C@@H](C2)C#N)C2CC2)C1 |r,wU:32.37,wD:23.24,1.0,3.3,(-9.64,4.14,;-8.87,2.81,;-9.64,1.47,;-8.87,.14,;-9.64,-1.2,;-7.33,.14,;-6.56,1.47,;-5.02,1.47,;-4.28,.14,;-5.05,-1.19,;-4.28,-2.53,;-2.74,-2.53,;-1.97,-1.19,;-2.74,.14,;-.43,-1.19,;.34,.14,;.34,-2.53,;1.88,-2.53,;2.65,-3.86,;4.19,-3.86,;4.96,-2.53,;4.19,-1.19,;2.65,-1.19,;4.96,.14,;5.73,-1.19,;7.27,-1.19,;8.17,.05,;9.64,-.42,;9.64,-1.96,;8.17,-2.44,;7.7,-3.9,;6.05,1.23,;4.96,2.32,;3.87,1.23,;4.96,3.86,;4.96,5.4,;-5.05,-3.86,;-6.39,-4.63,;-5.05,-5.4,;-7.33,2.81,)|

Structure