| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mannan-binding lectin serine protease 2 |
|---|
| Ligand | BDBM595073 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzymatic Assay for MASP-2 |
|---|
| Ki | <500±n/a nM |
|---|
| Citation |  Cutshall, NS; Gage, JL; Gruswitz, FA; Khalaf, J; Little, TL; Metz, M; Nguyen, JH; Nollert von Specht, PK; Tsoung, J; Cicirelli, M; Goldstein, SR; Keshipeddy, SK; Kwon, DY; Lemus, RH; Vaddela, SB MASP-2 inhibitors and methods of use US Patent US11584714 Publication Date 2/21/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mannan-binding lectin serine protease 2 |
|---|
| Name: | Mannan-binding lectin serine protease 2 |
|---|
| Synonyms: | MASP-2 | MASP2_MOUSE | MBL-associated serine protease 2 | Mannose-binding protein-associated serine protease 2 | Masp2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 75509.67 |
|---|
| Organism: | Mouse |
|---|
| Description: | Q91WP0 |
|---|
| Residue: | 685 |
|---|
| Sequence: | MRLLIFLGLLWSLVATLLGSKWPEPVFGRLVSPGFPEKYADHQDRSWTLTAPPGYRLRLY
FTHFDLELSYRCEYDFVKLSSGTKVLATLCGQESTDTEQAPGNDTFYSLGPSLKVTFHSD
YSNEKPFTGFEAFYAAEDVDECRVSLGDSVPCDHYCHNYLGGYYCSCRAGYVLHQNKHTC
SALCSGQVFTGRSGYLSSPEYPQPYPKLSSCTYSIRLEDGFSVILDFVESFDVETHPEAQ
CPYDSLKIQTDKGEHGPFCGKTLPPRIETDSHKVTITFATDESGNHTGWKIHYTSTARPC
PDPTAPPNGSISPVQAIYVLKDRFSVFCKTGFELLQGSVPLKSFTAVCQKDGSWDRPMPE
CSIIDCGPPDDLPNGHVDYITGPEVTTYKAVIQYSCEETFYTMSSNGKYVCEADGFWTSS
KGEKLPPVCEPVCGLSTHTIGGRIVGGQPAKPGDFPWQVLLLGQTTAAAGALIHDNWVLT
AAHAVYEKRMAASSLNIRMGILKRLSPHYTQAWPEEIFIHEGYTHGAGFDNDIALIKLKN
KVTINGSIMPVCLPRKEAASLMRTDFTGTVAGWGLTQKGLLARNLMFVDIPIADHQKCTA
VYEKLYPGVRVSANMLCAGLETGGKDSCRGDSGGALVFLDNETQRWFVGGIVSWGSINCG
AADQYGVYTKVINYIPWIENIISNF
|
|
|
|---|
| BDBM595073 |
|---|
| n/a |
|---|
| Name | BDBM595073 |
|---|
| Synonyms: | US11584714, Compound 1101 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H29N5O3 |
|---|
| Mol. Mass. | 423.5081 |
|---|
| SMILES | C[C@H](NC(=O)[C@H]1C[C@@](O)(CCN1)c1ccccc1)C(=O)NCc1ccc(cc1)C(N)=N |r| |
|---|
| Structure | 
|
|---|
Search and Browse
