| Reaction Details |
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 | Report a problem with these data |
| Target | Mannan-binding lectin serine protease 2 |
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| Ligand | BDBM595397 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Assay for MASP-2 |
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| Ki | <500±n/a nM |
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| Citation |  Cutshall, NS; Gage, JL; Gruswitz, FA; Khalaf, J; Little, TL; Metz, M; Nguyen, JH; Nollert von Specht, PK; Tsoung, J; Cicirelli, M; Goldstein, SR; Keshipeddy, SK; Kwon, DY; Lemus, RH; Vaddela, SB MASP-2 inhibitors and methods of use US Patent US11584714 Publication Date 2/21/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mannan-binding lectin serine protease 2 |
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| Name: | Mannan-binding lectin serine protease 2 |
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| Synonyms: | MASP-2 | MASP2_MOUSE | MBL-associated serine protease 2 | Mannose-binding protein-associated serine protease 2 | Masp2 |
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| Type: | Protein |
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| Mol. Mass.: | 75509.67 |
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| Organism: | Mouse |
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| Description: | Q91WP0 |
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| Residue: | 685 |
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| Sequence: | MRLLIFLGLLWSLVATLLGSKWPEPVFGRLVSPGFPEKYADHQDRSWTLTAPPGYRLRLY
FTHFDLELSYRCEYDFVKLSSGTKVLATLCGQESTDTEQAPGNDTFYSLGPSLKVTFHSD
YSNEKPFTGFEAFYAAEDVDECRVSLGDSVPCDHYCHNYLGGYYCSCRAGYVLHQNKHTC
SALCSGQVFTGRSGYLSSPEYPQPYPKLSSCTYSIRLEDGFSVILDFVESFDVETHPEAQ
CPYDSLKIQTDKGEHGPFCGKTLPPRIETDSHKVTITFATDESGNHTGWKIHYTSTARPC
PDPTAPPNGSISPVQAIYVLKDRFSVFCKTGFELLQGSVPLKSFTAVCQKDGSWDRPMPE
CSIIDCGPPDDLPNGHVDYITGPEVTTYKAVIQYSCEETFYTMSSNGKYVCEADGFWTSS
KGEKLPPVCEPVCGLSTHTIGGRIVGGQPAKPGDFPWQVLLLGQTTAAAGALIHDNWVLT
AAHAVYEKRMAASSLNIRMGILKRLSPHYTQAWPEEIFIHEGYTHGAGFDNDIALIKLKN
KVTINGSIMPVCLPRKEAASLMRTDFTGTVAGWGLTQKGLLARNLMFVDIPIADHQKCTA
VYEKLYPGVRVSANMLCAGLETGGKDSCRGDSGGALVFLDNETQRWFVGGIVSWGSINCG
AADQYGVYTKVINYIPWIENIISNF
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| BDBM595397 |
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| n/a |
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| Name | BDBM595397 |
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| Synonyms: | US11584714, Compound 1485 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H29N5O2 |
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| Mol. Mass. | 407.5087 |
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| SMILES | C[C@H](NC(=O)[C@H]1C[C@@H](CCN1)c1ccccc1)C(=O)NCc1ccc(cc1)C(N)=N |r| |
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| Structure | 
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