| Reaction Details |
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 | Report a problem with these data |
| Target | Egl nine homolog 1 [181-417] |
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| Ligand | BDBM475542 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Activity Assay |
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| IC50 | 25.1±n/a nM |
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| Citation |  Hocutt, FM; Leonard, Jr., BE; Peltier, HM; Phuong, VK; Rabinowitz, MH; Rosen, MD; Tarantino, KT; Venkatesan, H; Zhao, LX Benzoimidazoles as prolyl hydroxylase inhibitors US Patent US11618744 Publication Date 4/4/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Egl nine homolog 1 [181-417] |
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| Name: | Egl nine homolog 1 [181-417] |
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| Synonyms: | C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (aa 181-417) |
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| Type: | Enzyme |
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| Mol. Mass.: | 26555.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 181-417 |
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| Residue: | 237 |
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| Sequence: | PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQL
VSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMV
ACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKF
DRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKP
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| BDBM475542 |
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| n/a |
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| Name | BDBM475542 |
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| Synonyms: | 1-(5-Ethylsulfonyl-6-trifluoromethyl-1H-benzoimidazol-2- | US10851083, Example 154 | US11618744, Example 154 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H11F3N4O4S |
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| Mol. Mass. | 388.322 |
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| SMILES | CCS(=O)(=O)c1cc2nc([nH]c2cc1C(F)(F)F)-n1cc(cn1)C(O)=O |
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| Structure | 
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