Reaction Details | |||
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Target | Tyrosine-protein kinase BTK | ||
Ligand | BDBM164714 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Biological Assay | ||
IC50 | 0.150±n/a nM | ||
Citation | Liu, Q; Watterson, SH; Macor, JE; Ngu, K; Ahmad, S Indole carboxamide compounds US Patent US11623921 Publication Date 4/11/2023 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase BTK | |||
Name: | Tyrosine-protein kinase BTK | ||
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
Type: | Enzyme | ||
Mol. Mass.: | 76289.95 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q06187 | ||
Residue: | 659 | ||
Sequence: |
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BDBM164714 | |||
n/a | |||
Name | BDBM164714 | ||
Synonyms: | US10604504, Example 102 | US11623921, Example 102 | US9688629, 155 | US9688629, 156 | US9802915, Example 156 | US9920031, Example 156 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H20FN3O3 | ||
Mol. Mass. | 393.4109 | ||
SMILES | Cc1[nH]c2c(cc(F)c(-c3cccc4N(CCOc34)C(=O)C=C)c2c1C)C(N)=O |(-4.62,3.08,;-3.08,3.08,;-2.18,4.33,;-.71,3.85,;.62,4.62,;1.95,3.85,;1.95,2.31,;3.29,1.54,;.62,1.54,;.62,,;-.71,-.77,;-.71,-2.31,;.62,-3.08,;1.95,-2.31,;3.29,-3.08,;4.62,-2.31,;4.62,-.77,;3.29,,;1.95,-.77,;3.29,-4.62,;1.95,-5.39,;4.62,-5.39,;4.62,-6.93,;-.71,2.31,;-2.18,1.83,;-2.95,.5,;.62,6.16,;1.95,6.93,;-.71,6.93,)| | ||
Structure |