Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Acetylcholinesterase |
---|
Ligand | BDBM9045 |
---|
Substrate/Competitor | BDBM8959 |
---|
Meas. Tech. | Enzyme Inhibition Assay |
---|
pH | 7.4±n/a |
---|
Temperature | 310.15±n/a K |
---|
IC50 | 75±11 nM |
---|
Citation | Hu, MK; Wu, LJ; Hsiao, G; Yen, MH Homodimeric tacrine congeners as acetylcholinesterase inhibitors. J Med Chem45:2277-82 (2002) [PubMed] Article |
---|
More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
---|
|
Acetylcholinesterase |
---|
Name: | Acetylcholinesterase |
Synonyms: | ACES_RAT | Acetylcholinesterase (AChE) | Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) | Acetylcholinesterase precursor | Acetylcholinesterase, AChE | Ache |
Type: | Enzyme |
Mol. Mass.: | 68193.62 |
Organism: | Rattus norvegicus (rat) |
Description: | P37136 |
Residue: | 614 |
Sequence: | MRPPWYPLHTPSLASPLLFLLLSLLGGGARAEGREDPQLLVRVRGGQLRGIRLKAPGGPV
SAFLGIPFAEPPVGSRRFMPPEPKRPWSGILDATTFQNVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLIWIYGGGFYSGASSLDVYDGRFLAQVEGTVLVSM
NYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASV
GMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTEL
ISCLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPDALINTGDFQDLQVLVG
VVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPE
DPAHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGY
EIEFIFGLPLDPSLNYTVEERIFAQRLMQYWTNFARTGDPNDPRDSKSPRWPPYTTAAQQ
YVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQERCSDL
|
|
|
BDBM9045 |
---|
BDBM8959 |
---|
Name | BDBM9045 |
Synonyms: | Homodimeric Tacrine Analog 2b | N,N-Bis-(2,3-dihydro-1H-cyclopenta[1,2-b]quinolin-8-yl)-1,7-diaminoheptane | N-(7-{1H,2H,3H-cyclopenta[b]quinolin-9-ylamino}heptyl)-1H,2H,3H-cyclopenta[b]quinolin-9-amine |
Type | Small organic molecule |
Emp. Form. | C31H36N4 |
Mol. Mass. | 464.6443 |
SMILES | C(CCCNc1c2CCCc2nc2ccccc12)CCCNc1c2CCCc2nc2ccccc12 |
Structure |
|