BindingDB PrimarySearch

Found 112 hits with Last Name = 'hu' and Initial = 'mk'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 3A (Homo sapiens (Human))	BDBM50103072 (1-Benzyl-2-piperazin-1-yl-1H-benzoimidazole \| CHEM...) Show SMILES C(c1ccccc1)n1c(nc2ccccc12)N1CCNCC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	0.360	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Louisiana at Monroe Curated by ChEMBL					Assay Description Binding affinity of the compound against human 5-hydroxytryptamine 3A receptor				Bioorg Med Chem Lett 11: 2133-6 (2001) BindingDB Entry DOI: 10.7270/Q20G3JGG
The University of Louisiana at Monroe Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 3A (Homo sapiens (Human))	BDBM50103070 (1-(4-Methoxy-benzyl)-2-piperazin-1-yl-1H-benzoimid...) Show SMILES COc1ccc(Cn2c(nc3ccccc23)N2CCNCC2)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.420	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Louisiana at Monroe Curated by ChEMBL					Assay Description Binding affinity of the compound against human 5-hydroxytryptamine 3A receptor				Bioorg Med Chem Lett 11: 2133-6 (2001) BindingDB Entry DOI: 10.7270/Q20G3JGG
The University of Louisiana at Monroe Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 3A (Homo sapiens (Human))	BDBM50103076 (1-Naphthalen-2-ylmethyl-2-piperazin-1-yl-1H-benzoi...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Louisiana at Monroe Curated by ChEMBL					Assay Description Binding affinity of the compound against human 5-hydroxytryptamine 3A receptor				Bioorg Med Chem Lett 11: 2133-6 (2001) BindingDB Entry DOI: 10.7270/Q20G3JGG
The University of Louisiana at Monroe Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 3A (Homo sapiens (Human))	BDBM50103075 (1-(4-Methyl-benzyl)-2-piperazin-1-yl-1H-benzoimida...) Show SMILES Cc1ccc(Cn2c(nc3ccccc23)N2CCNCC2)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Louisiana at Monroe Curated by ChEMBL					Assay Description Binding affinity of the compound against human 5-hydroxytryptamine 3A receptor				Bioorg Med Chem Lett 11: 2133-6 (2001) BindingDB Entry DOI: 10.7270/Q20G3JGG
The University of Louisiana at Monroe Curated by ChEMBL					More data for this Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B (Homo sapiens (Human))	BDBM50029191 (15-Benzyl-30-ethyl-12-hydroxymethyl-33-(1-hydroxy-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description The compound was tested for inhibition of Peptidyl-propyl isomerase (PPIase).				J Med Chem 38: 4164-70 (1995) BindingDB Entry DOI: 10.7270/Q2X34WGK
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 3A (Homo sapiens (Human))	BDBM50103069 (1-(4-Fluoro-benzyl)-2-piperazin-1-yl-1H-benzoimida...) Show SMILES Fc1ccc(Cn2c(nc3ccccc23)N2CCNCC2)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	5.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Louisiana at Monroe Curated by ChEMBL					Assay Description Binding affinity of the compound against human 5-hydroxytryptamine 3A receptor				Bioorg Med Chem Lett 11: 2133-6 (2001) BindingDB Entry DOI: 10.7270/Q20G3JGG
The University of Louisiana at Monroe Curated by ChEMBL					More data for this Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B (Homo sapiens (Human))	BDBM50029190 (15-Benzyl-30-ethyl-33-(1-hydroxy-2-methyl-hex-4-en...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description The compound was tested for inhibition of Peptidyl-propyl isomerase (PPIase).				J Med Chem 38: 4164-70 (1995) BindingDB Entry DOI: 10.7270/Q2X34WGK
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B (Homo sapiens (Human))	BDBM50029192 (15-Benzyl-30-ethyl-12-hydroxymethyl-33-(1-hydroxy-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description The compound was tested for inhibition of Peptidyl-propyl isomerase (PPIase).				J Med Chem 38: 4164-70 (1995) BindingDB Entry DOI: 10.7270/Q2X34WGK
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B (Homo sapiens (Human))	BDBM50022815 ((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid UniChem Patents Similars	PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description The compound was tested for inhibition of Peptidyl-propyl isomerase (PPIase).				J Med Chem 38: 4164-70 (1995) BindingDB Entry DOI: 10.7270/Q2X34WGK
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 3A (Homo sapiens (Human))	BDBM50103073 (1-Phenethyl-2-piperazin-1-yl-1H-benzoimidazole \| C...) Show SMILES C(Cn1c(nc2ccccc12)N1CCNCC1)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	7.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Louisiana at Monroe Curated by ChEMBL					Assay Description Binding affinity of the compound against human 5-hydroxytryptamine 3A receptor				Bioorg Med Chem Lett 11: 2133-6 (2001) BindingDB Entry DOI: 10.7270/Q20G3JGG
The University of Louisiana at Monroe Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 3A (Homo sapiens (Human))	BDBM50103071 (1-(3-Phenyl-propyl)-2-piperazin-1-yl-1H-benzoimida...) Show SMILES C(Cc1ccccc1)Cn1c(nc2ccccc12)N1CCNCC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Louisiana at Monroe Curated by ChEMBL					Assay Description Binding affinity of the compound against human 5-hydroxytryptamine 3A receptor				Bioorg Med Chem Lett 11: 2133-6 (2001) BindingDB Entry DOI: 10.7270/Q20G3JGG
The University of Louisiana at Monroe Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 3A (Homo sapiens (Human))	BDBM50103077 (2-Piperazin-1-yl-1H-benzoimidazole \| CHEMBL292066) Show SMILES C1CN(CCN1)c1nc2ccccc2[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Louisiana at Monroe Curated by ChEMBL					Assay Description Binding affinity of the compound against human 5-hydroxytryptamine 3A receptor				Bioorg Med Chem Lett 11: 2133-6 (2001) BindingDB Entry DOI: 10.7270/Q20G3JGG
The University of Louisiana at Monroe Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 3A (Homo sapiens (Human))	BDBM50053608 (1N-amino(immino)methyl-3-chloroaniline \| CHEMBL138...) Show SMILES [#7]\[#6](-[#7])=[#7]\c1cccc(Cl)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	32	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Displacement of [3H]GR65630 from 5-HT3 receptor (unknown origin) expressed in mouse/rat NG108-15 cells after 30 mins by by liquid scintillation count...				Bioorg Med Chem Lett 23: 5945-8 (2013) Article DOI: 10.1016/j.bmcl.2013.08.072 BindingDB Entry DOI: 10.7270/Q2ZK5J31
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B (Homo sapiens (Human))	BDBM50029194 (15-Benzyl-30-ethyl-33-(1-hydroxy-2-methyl-hex-4-en...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	33	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Madison Curated by ChEMBL					Assay Description The compound was tested for inhibition of Peptidyl-propyl isomerase (PPIase).				J Med Chem 38: 4164-70 (1995) BindingDB Entry DOI: 10.7270/Q2X34WGK
University of Wisconsin-Madison Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 3A (Homo sapiens (Human))	BDBM50441458 (CHEMBL2436555) Show SMILES NC1=NCc2cc(Cl)ccc2N1 \|t:1\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	34	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Displacement of [3H]GR65630 from 5-HT3 receptor (unknown origin) expressed in mouse/rat NG108-15 cells after 30 mins by by liquid scintillation count...				Bioorg Med Chem Lett 23: 5945-8 (2013) Article DOI: 10.1016/j.bmcl.2013.08.072 BindingDB Entry DOI: 10.7270/Q2ZK5J31
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50324701 (CHEMBL1221472 \| Exiguamine A) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	41	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human recombinant indoleamine-2,3-dioxygenase				Nat Chem Biol 4: 535-7 (2008) Article DOI: 10.1038/nchembio.107 BindingDB Entry DOI: 10.7270/Q2P55NR5
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM21975 ((4S)-16'-(2-aminoethyl)-9'-hydroxy-1,3,6',6'-tetra...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	41	-43.9	n/a	n/a	n/a	n/a	n/a	6.5	37
University of British Columbia					Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...				J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65
University of British Columbia					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50324700 (CHEMBL1221412 \| Exiguamine B) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human recombinant indoleamine-2,3-dioxygenase				Nat Chem Biol 4: 535-7 (2008) Article DOI: 10.1038/nchembio.107 BindingDB Entry DOI: 10.7270/Q2P55NR5
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM50324699 (CHEMBL1221473 \| Seco-exiguamine) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of human recombinant indoleamine-2,3-dioxygenase				Nat Chem Biol 4: 535-7 (2008) Article DOI: 10.1038/nchembio.107 BindingDB Entry DOI: 10.7270/Q2P55NR5
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 3A (Homo sapiens (Human))	BDBM50441458 (CHEMBL2436555) Show SMILES NC1=NCc2cc(Cl)ccc2N1 \|t:1\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Displacement of [3H]GR65630 from human 5-HT3 receptor expressed in African green monkey COS cells after 90 mins by scintillation counting analysis				Bioorg Med Chem Lett 23: 5945-8 (2013) Article DOI: 10.1016/j.bmcl.2013.08.072 BindingDB Entry DOI: 10.7270/Q2ZK5J31
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM21979 (4,7-dihydro-1H-indole-4,7-dione \| Indolequinone, 1...) Show SMILES O=C1C=CC(=O)c2[nH]ccc12 \|c:2\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	190	-39.9	n/a	n/a	n/a	n/a	n/a	6.5	37
University of British Columbia					Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...				J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65
University of British Columbia					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM21982 (3-(2-aminoethyl)-5-(3-methyl-2,5-dioxo-1-propylimi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	200	-39.8	n/a	n/a	n/a	n/a	n/a	6.5	37
University of British Columbia					Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...				J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65
University of British Columbia					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM21981 (Tryptamine quinone, 21 \| methyl 4-[3-(2-{[(benzylo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	260	-39.1	n/a	n/a	n/a	n/a	n/a	6.5	37
University of British Columbia					Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...				J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65
University of British Columbia					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM21984 (Tryptamine quinone, 25 \| methyl 4-{4,7-dioxo-3-[2-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	260	-39.1	n/a	n/a	n/a	n/a	n/a	6.5	37
University of British Columbia					Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...				J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65
University of British Columbia					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM21980 (Indolequinone, 20 \| methyl 4-(4,7-dioxo-4,7-dihydr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	420	-37.9	n/a	n/a	n/a	n/a	n/a	6.5	37
University of British Columbia					Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...				J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65
University of British Columbia					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM21976 (Tryptamine quinone, 9 \| benzyl N-[2-(4,7-dioxo-4,7...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.49E+3	-34.6	n/a	n/a	n/a	n/a	n/a	6.5	37
University of British Columbia					Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...				J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65
University of British Columbia					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 3A (Homo sapiens (Human))	BDBM50115644 ((+/-)-12-Methyl-1,2,3,4,9,13b-hexahydro-2,4a,5-tri...) Show SMILES CN1CCN2C(C1)c1ccccc1Cc1cccnc21 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	DrugBank Article PubMed	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Displacement of [3H]GR65630 from human 5-HT3A receptor expressed in HEK293 cells by liquid scintillation counting analysis				Bioorg Med Chem Lett 23: 5945-8 (2013) Article DOI: 10.1016/j.bmcl.2013.08.072 BindingDB Entry DOI: 10.7270/Q2ZK5J31
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Cavia porcellus (Guinea pig))	BDBM50441458 (CHEMBL2436555) Show SMILES NC1=NCc2cc(Cl)ccc2N1 \|t:1\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.15E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Displacement of [3H]Pentazocine from guinea pig sigma1 receptor after 90 mins by scintillation counting analysis				Bioorg Med Chem Lett 23: 5945-8 (2013) Article DOI: 10.1016/j.bmcl.2013.08.072 BindingDB Entry DOI: 10.7270/Q2ZK5J31
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholine receptor subunit alpha/Neuronal acetylcholine receptor subunit beta-4 (Homo sapiens (Human))	BDBM50441458 (CHEMBL2436555) Show SMILES NC1=NCc2cc(Cl)ccc2N1 \|t:1\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Displacement of [3H]-epibatidine from human alpha2beta4 nAChR transfected in HEK293 cells by scintillation counting analysis				Bioorg Med Chem Lett 23: 5945-8 (2013) Article DOI: 10.1016/j.bmcl.2013.08.072 BindingDB Entry DOI: 10.7270/Q2ZK5J31
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Homo sapiens (Human))	BDBM50441458 (CHEMBL2436555) Show SMILES NC1=NCc2cc(Cl)ccc2N1 \|t:1\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Displacement of [3H]-epibatidine from human alpha4beta2 nAChR transfected in HEK293 cells by scintillation counting analysis				Bioorg Med Chem Lett 23: 5945-8 (2013) Article DOI: 10.1016/j.bmcl.2013.08.072 BindingDB Entry DOI: 10.7270/Q2ZK5J31
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50441458 (CHEMBL2436555) Show SMILES NC1=NCc2cc(Cl)ccc2N1 \|t:1\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Displacement of [[3H]N-methylspiperone from human recombinant dopamine D2 receptor expressed in human fibroblasts after 90 mins by scintillation coun...				Bioorg Med Chem Lett 23: 5945-8 (2013) Article DOI: 10.1016/j.bmcl.2013.08.072 BindingDB Entry DOI: 10.7270/Q2ZK5J31
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50441458 (CHEMBL2436555) Show SMILES NC1=NCc2cc(Cl)ccc2N1 \|t:1\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Displacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in HEK cells after 90 mins by scintillation counting analysis				Bioorg Med Chem Lett 23: 5945-8 (2013) Article DOI: 10.1016/j.bmcl.2013.08.072 BindingDB Entry DOI: 10.7270/Q2ZK5J31
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholine receptor subunit alpha/Neuronal acetylcholine receptor subunit beta-2 (Homo sapiens (Human))	BDBM50441458 (CHEMBL2436555) Show SMILES NC1=NCc2cc(Cl)ccc2N1 \|t:1\| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Displacement of [3H]-epibatidine from human alpha2beta2 nAChR transfected in HEK293 cells by scintillation counting analysis				Bioorg Med Chem Lett 23: 5945-8 (2013) Article DOI: 10.1016/j.bmcl.2013.08.072 BindingDB Entry DOI: 10.7270/Q2ZK5J31
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM21977 (Tryptamine quinone, 13 \| benzyl N-{2-[5-(1,3-dioxo...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.09E+4	-29.5	n/a	n/a	n/a	n/a	n/a	6.5	37
University of British Columbia					Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...				J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65
University of British Columbia					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM21973 (1-Methyltryptophan, 1 \| 2-amino-3-(1-methyl-1H-ind...) Show SMILES Cn1cc(CC(N)C(O)=O)c2ccccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	6.20E+4	-25.0	n/a	n/a	n/a	n/a	n/a	6.5	37
University of British Columbia					Assay Description The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...				J Med Chem 51: 2634-7 (2008) Article DOI: 10.1021/jm800143h BindingDB Entry DOI: 10.7270/Q2MK6B65
University of British Columbia					More data for this Ligand-Target Pair
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM9054 (6-chloro-N-{7-[(6-chloro-1,2,3,4-tetrahydroacridin...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0700	n/a	n/a	n/a	n/a	7.4	37
National Defense Medical Center					Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...				J Med Chem 45: 2277-82 (2002) Article DOI: 10.1021/jm010308g BindingDB Entry DOI: 10.7270/Q2KW5D89
National Defense Medical Center					More data for this Ligand-Target Pair
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM8963 (CHEMBL32823 \| Homodimeric Tacrine Analog 3b \| N-[7...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	7.4	37
National Defense Medical Center					Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...				J Med Chem 45: 2277-82 (2002) Article DOI: 10.1021/jm010308g BindingDB Entry DOI: 10.7270/Q2KW5D89
National Defense Medical Center					More data for this Ligand-Target Pair
Melanocyte-stimulating hormone receptor (Mus musculus)	BDBM50354719 (CHEMBL1834391) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.210	n/a	n/a	n/a	n/a	n/a	n/a
The University of Iowa Curated by ChEMBL					Assay Description Displacement of [125I]-[Nle4-D-Phe7]-alpha-MSH from MC1R in mouse B16-F10 cells after 1.5 hrs by gamma counting				Bioorg Med Chem Lett 21: 5757-61 (2011) Article DOI: 10.1016/j.bmcl.2011.08.017 BindingDB Entry DOI: 10.7270/Q2H132DZ
The University of Iowa Curated by ChEMBL					More data for this Ligand-Target Pair
Melanocyte-stimulating hormone receptor (Mus musculus)	BDBM50354718 (CHEMBL1834392) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a	n/a
The University of Iowa Curated by ChEMBL					Assay Description Displacement of [125I]-[Nle4-D-Phe7]-alpha-MSH from MC1R in mouse B16-F10 cells after 1.5 hrs by gamma counting				Bioorg Med Chem Lett 21: 5757-61 (2011) Article DOI: 10.1016/j.bmcl.2011.08.017 BindingDB Entry DOI: 10.7270/Q2H132DZ
The University of Iowa Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM9055 (6-chloro-N-{8-[(6-chloro-1,2,3,4-tetrahydroacridin...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.4	37
National Defense Medical Center					Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...				J Med Chem 45: 2277-82 (2002) Article DOI: 10.1021/jm010308g BindingDB Entry DOI: 10.7270/Q2KW5D89
National Defense Medical Center					More data for this Ligand-Target Pair
Melanocyte-stimulating hormone receptor (Mus musculus)	BDBM50354717 (CHEMBL1834393) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.590	n/a	n/a	n/a	n/a	n/a	n/a
The University of Iowa Curated by ChEMBL					Assay Description Displacement of [125I]-[Nle4-D-Phe7]-alpha-MSH from MC1R in mouse B16-F10 cells after 1.5 hrs by gamma counting				Bioorg Med Chem Lett 21: 5757-61 (2011) Article DOI: 10.1016/j.bmcl.2011.08.017 BindingDB Entry DOI: 10.7270/Q2H132DZ
The University of Iowa Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM9051 (6-fluoro-N-{7-[(6-fluoro-1,2,3,4-tetrahydroacridin...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.4	37
National Defense Medical Center					Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...				J Med Chem 45: 2277-82 (2002) Article DOI: 10.1021/jm010308g BindingDB Entry DOI: 10.7270/Q2KW5D89
National Defense Medical Center					More data for this Ligand-Target Pair
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM9053 (6-chloro-N-{6-[(6-chloro-1,2,3,4-tetrahydroacridin...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.4	37
National Defense Medical Center					Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...				J Med Chem 45: 2277-82 (2002) Article DOI: 10.1021/jm010308g BindingDB Entry DOI: 10.7270/Q2KW5D89
National Defense Medical Center					More data for this Ligand-Target Pair
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM9052 (6-fluoro-N-{8-[(6-fluoro-1,2,3,4-tetrahydroacridin...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	7.4	37
National Defense Medical Center					Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...				J Med Chem 45: 2277-82 (2002) Article DOI: 10.1021/jm010308g BindingDB Entry DOI: 10.7270/Q2KW5D89
National Defense Medical Center					More data for this Ligand-Target Pair
Melanocyte-stimulating hormone receptor (Mus musculus)	BDBM50354716 (CHEMBL1834394) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.760	n/a	n/a	n/a	n/a	n/a	n/a
The University of Iowa Curated by ChEMBL					Assay Description Displacement of [125I]-[Nle4-D-Phe7]-alpha-MSH from MC1R in mouse B16-F10 cells after 1.5 hrs by gamma counting				Bioorg Med Chem Lett 21: 5757-61 (2011) Article DOI: 10.1016/j.bmcl.2011.08.017 BindingDB Entry DOI: 10.7270/Q2H132DZ
The University of Iowa Curated by ChEMBL					More data for this Ligand-Target Pair
Melanocyte-stimulating hormone receptor (Mus musculus)	BDBM50354715 (CHEMBL1834395) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.820	n/a	n/a	n/a	n/a	n/a	n/a
The University of Iowa Curated by ChEMBL					Assay Description Displacement of [125I]-[Nle4-D-Phe7]-alpha-MSH from MC1R in mouse B16-F10 cells after 1.5 hrs by gamma counting				Bioorg Med Chem Lett 21: 5757-61 (2011) Article DOI: 10.1016/j.bmcl.2011.08.017 BindingDB Entry DOI: 10.7270/Q2H132DZ
The University of Iowa Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM9050 (6-fluoro-N-{6-[(6-fluoro-1,2,3,4-tetrahydroacridin...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	7.4	37
National Defense Medical Center					Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...				J Med Chem 45: 2277-82 (2002) Article DOI: 10.1021/jm010308g BindingDB Entry DOI: 10.7270/Q2KW5D89
National Defense Medical Center					More data for this Ligand-Target Pair
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM9057 (Homodimeric Tacrine Analog 3k \| N,N-Bis-(1,2,3,4-t...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	7.4	37
National Defense Medical Center					Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...				J Med Chem 45: 2277-82 (2002) Article DOI: 10.1021/jm010308g BindingDB Entry DOI: 10.7270/Q2KW5D89
National Defense Medical Center					More data for this Ligand-Target Pair
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM9047 (Bis-THA inhibitor 5 \| CHEMBL73800 \| Hexylene-Linke...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.4	37
National Defense Medical Center					Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...				J Med Chem 45: 2277-82 (2002) Article DOI: 10.1021/jm010308g BindingDB Entry DOI: 10.7270/Q2KW5D89
National Defense Medical Center					More data for this Ligand-Target Pair
Acetylcholinesterase (Rattus norvegicus (rat))	BDBM9061 (Homodimeric Tacrine Analog 4c \| N,N-Bis-(2,3,4,5-t...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.4	37
National Defense Medical Center					Assay Description The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...				J Med Chem 45: 2277-82 (2002) Article DOI: 10.1021/jm010308g BindingDB Entry DOI: 10.7270/Q2KW5D89
National Defense Medical Center					More data for this Ligand-Target Pair

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