| Reaction Details |
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 | Report a problem with these data |
| Target | Estrogen receptor [Y537S] |
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| Ligand | BDBM443432 |
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| Substrate/Competitor | n/a |
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| Ki | 6.78±n/a nM |
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| Citation |  Bastian, JA; Cohen, JD; Rubio, A; Sall, DJ; McMahon, JA Selective estrogen receptor degraders US Patent US11634426 Publication Date 4/25/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Estrogen receptor [Y537S] |
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| Name: | Estrogen receptor [Y537S] |
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| Synonyms: | ESR | ESR1 | ESR1_HUMAN | Estrogen receptor (Y537S) | Estrogen receptor alpha Y537S | NR3A1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 66154.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03372[Y537S] |
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| Residue: | 595 |
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| Sequence: | MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
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| BDBM443432 |
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| n/a |
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| Name | BDBM443432 |
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| Synonyms: | Racemic 5-(4-{2- [3-(fluoromethyl) azetidin-1- yl]ethoxy}phenyl)-7- (trifluoromethyl)-5H- [1]benzopyrano[4,3- c]quinolin-2-ol | US10654866, Example 2 | US11117902, Example 2 | US11634426, Example 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H24F4N2O3 |
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| Mol. Mass. | 524.5061 |
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| SMILES | Oc1ccc2c3C(Oc4c(cccc4C(F)(F)F)-c3cnc2c1)c1ccc(OCCN2CC(CF)C2)cc1 |
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| Structure | 
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