| Reaction Details |
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 | Report a problem with these data |
| Target | Mannan-binding lectin serine protease 2 |
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| Ligand | BDBM604240 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Assay for MASP-2 |
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| Ki | <500±n/a nM |
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| Citation |  Cutshall, NS; Gage, JL; Goldstein, SR; Keshipeddy, SK; Kwon, DY; Lemus, RH; Little, TL; Metz, M; Nollert Von Specht, PK; Price, LM; Tsoung, J MASP-2 inhibitors and methods of use US Patent US11661418 Publication Date 5/30/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mannan-binding lectin serine protease 2 |
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| Name: | Mannan-binding lectin serine protease 2 |
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| Synonyms: | 3.4.21.104 | MASP-2 | MASP2 | MASP2_HUMAN | MBL-associated serine protease 2 | Mannan-binding lectin serine protease 2 A chain | Mannan-binding lectin serine protease 2 B chain | Mannose-binding protein-associated serine protease 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 75689.43 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117891 |
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| Residue: | 686 |
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| Sequence: | MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLY
FTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSD
YSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTC
SALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETL
CPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPC
PYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPA
CSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTS
SKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLT
AAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNN
KVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTA
AYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNC
GEAGQYGVYTKVINYIPWIENIISDF
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| BDBM604240 |
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| n/a |
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| Name | BDBM604240 |
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| Synonyms: | Preparation of (2R,4S)—N—((S)-1-((4-((Z)—N′-((L-valyl)oxy)carbamimidoyl)benzyl)amino)-1-oxopropan-2-yl)-4-phenylpiperidine-2-carboxamide dihydrochloride salt | US11661418, Compound I-7 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H38N6O4 |
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| Mol. Mass. | 522.6391 |
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| SMILES | CC(C)[C@H](N)C(=O)O\N=C(/N)c1ccc(CNC(=O)[C@H](C)NC(=O)[C@H]2C[C@H](CCN2)c2ccccc2)cc1 |r| |
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| Structure | 
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