| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mannan-binding lectin serine protease 2 |
|---|
| Ligand | BDBM604243 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzymatic Assay for MASP-2 |
|---|
| Ki | <500±n/a nM |
|---|
| Citation |  Cutshall, NS; Gage, JL; Goldstein, SR; Keshipeddy, SK; Kwon, DY; Lemus, RH; Little, TL; Metz, M; Nollert Von Specht, PK; Price, LM; Tsoung, J MASP-2 inhibitors and methods of use US Patent US11661418 Publication Date 5/30/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mannan-binding lectin serine protease 2 |
|---|
| Name: | Mannan-binding lectin serine protease 2 |
|---|
| Synonyms: | 3.4.21.104 | MASP-2 | MASP2 | MASP2_HUMAN | MBL-associated serine protease 2 | Mannan-binding lectin serine protease 2 A chain | Mannan-binding lectin serine protease 2 B chain | Mannose-binding protein-associated serine protease 2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 75689.43 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_117891 |
|---|
| Residue: | 686 |
|---|
| Sequence: | MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLY
FTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSD
YSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTC
SALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETL
CPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPC
PYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPA
CSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTS
SKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLT
AAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNN
KVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTA
AYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNC
GEAGQYGVYTKVINYIPWIENIISDF
|
|
|
|---|
| BDBM604243 |
|---|
| n/a |
|---|
| Name | BDBM604243 |
|---|
| Synonyms: | Preparation of 3-((2R,4S)-2-(((S)-1-((4-carbamimidoylbenzyl)amino)-1-oxopropan-2-yl)carbamoyl)-4-phenylpiperidin-1-yl)propanoic acid di-trifluoroacetate salt | US11661418, Compound I-14 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H33N5O4 |
|---|
| Mol. Mass. | 479.5713 |
|---|
| SMILES | C[C@H](NC(=O)[C@H]1C[C@H](CCN1CCC(O)=O)c1ccccc1)C(=O)NCc1ccc(cc1)C(N)=N |r| |
|---|
| Structure | 
|
|---|
Search and Browse
