Reaction Details |
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Target | Mannan-binding lectin serine protease 2 |
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Ligand | BDBM604248 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzymatic Assay for MASP-2 |
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Ki | 6250±n/a nM |
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Citation | Cutshall, NS; Gage, JL; Goldstein, SR; Keshipeddy, SK; Kwon, DY; Lemus, RH; Little, TL; Metz, M; Nollert Von Specht, PK; Price, LM; Tsoung, J MASP-2 inhibitors and methods of use US Patent US11661418 Publication Date 5/30/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Mannan-binding lectin serine protease 2 |
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Name: | Mannan-binding lectin serine protease 2 |
Synonyms: | 3.4.21.104 | MASP-2 | MASP2 | MASP2_HUMAN | MBL-associated serine protease 2 | Mannan-binding lectin serine protease 2 A chain | Mannan-binding lectin serine protease 2 B chain | Mannose-binding protein-associated serine protease 2 |
Type: | PROTEIN |
Mol. Mass.: | 75689.43 |
Organism: | Homo sapiens |
Description: | ChEMBL_117891 |
Residue: | 686 |
Sequence: | MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLY
FTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSD
YSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTC
SALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETL
CPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPC
PYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPA
CSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTS
SKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLT
AAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNN
KVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTA
AYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNC
GEAGQYGVYTKVINYIPWIENIISDF
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BDBM604248 |
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n/a |
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Name | BDBM604248 |
Synonyms: | Preparation of benzyl ((4-(((S)-2-((2R,4S)-1-ethyl-4-phenylpiperidine-2-carboxamido)propanamido)methyl)phenyl)(imino)methyl)carbamate | US11661418, Compound I-20 |
Type | Small organic molecule |
Emp. Form. | C33H39N5O4 |
Mol. Mass. | 569.6939 |
SMILES | CCN1CC[C@@H](C[C@@H]1C(=O)N[C@@H](C)C(=O)NCc1ccc(cc1)C(=N)NC(=O)OCc1ccccc1)c1ccccc1 |r| |
Structure |
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