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TargetMannan-binding lectin serine protease 2
LigandBDBM604249
Substrate/Competitorn/a
Meas. Tech.Enzymatic Assay for MASP-2
Ki<500±n/a nM
Citation Cutshall, NSGage, JLGoldstein, SRKeshipeddy, SKKwon, DYLemus, RHLittle, TLMetz, MNollert Von Specht, PKPrice, LMTsoung, J MASP-2 inhibitors and methods of use US Patent US11661418 Publication Date 5/30/2023
More Info.:Get all data from this article,  Assay Method
 
Mannan-binding lectin serine protease 2
Name:Mannan-binding lectin serine protease 2
Synonyms:3.4.21.104 | MASP-2 | MASP2 | MASP2_HUMAN | MBL-associated serine protease 2 | Mannan-binding lectin serine protease 2 A chain | Mannan-binding lectin serine protease 2 B chain | Mannose-binding protein-associated serine protease 2
Type:PROTEIN
Mol. Mass.:75689.43
Organism:Homo sapiens
Description:ChEMBL_117891
Residue:686
Sequence:
MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLY
FTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSD
YSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTC
SALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETL
CPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPC
PYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPA
CSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTS
SKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLT
AAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNN
KVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTA
AYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNC
GEAGQYGVYTKVINYIPWIENIISDF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM604249
n/a
NameBDBM604249
Synonyms:Preparation of (2R,4S)—N—((S)-1-((4-carbamimidoylbenzyl)amino)-1-OXOPROPAN-2-yl)-1-ethyl-4-phenylpiperidine-2-carboxamide | US11661418, Compound I-21
TypeSmall organic molecule
Emp. Form.C25H33N5O2
Mol. Mass.435.5618
SMILESCCN1CC[C@@H](C[C@@H]1C(=O)N[C@@H](C)C(=O)NCc1ccc(cc1)C(N)=N)c1ccccc1 |r|
Structure
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