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TargetDipeptidyl peptidase 1
LigandBDBM385063
Substrate/Competitorn/a
Meas. Tech.Fluorescence assay for recombinant human (RH) DPP1
IC50 67.6±n/a nM
Citation Lönn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Pontén, JF; Doyle, KJ; Van De Poël, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors US Patent US11673871 Publication Date 6/13/2023
More Info.:Get all data from this article,  Assay Method
 
Dipeptidyl peptidase 1
Name:Dipeptidyl peptidase 1
Synonyms:CATC_HUMAN | CPPI | CTSC | Cathepsin C | Cathepsin J | Dipeptidyl peptidase 1 (DDPI) | Dipeptidyl peptidase 1 (DPPI) | Dipeptidyl peptidase I | Dipeptidyl peptidase I (DPPI)
Type:Enzyme
Mol. Mass.:51857.28
Organism:Homo sapiens (Human)
Description:P53634
Residue:463
Sequence:
MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQ
EKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNE
TMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINA
IQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNV
HGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEG
GFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALM
KLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGM
DYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM385063
n/a
NameBDBM385063
Synonyms:(2S)-N-[(1S)-2-(4'-Carbamoy1-3'-fluorobiphenyl-4-yl)-1-cyanoethyl]-1,4-oxazepane-2- carboxamide | US10287258, Example 23 | US10669245, Example 23 | US11117874, Example 23 | US11655221, Example 23 | US11667615, Example 23 | US11680049, Example 23 | US20230278969, Example 23
TypeSmall organic molecule
Emp. Form.C22H23FN4O3
Mol. Mass.410.4414
SMILESNC(=O)c1ccc(cc1F)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1
Structure
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