Compile Data Set for Download or QSAR

Found 519 hits with Last Name = 'watson' and Initial = 'dw'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM427143 (1-({[(1R)-2-[(4-chloro-2-methanesulfonylphenyl)met...) Show SMILES C[C@@](O)(C1CCOCC1)c1cc2C(=O)N(Cc3ccc(Cl)cc3S(C)(=O)=O)[C@](OCC3(CC3)C(N)=O)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C34H35Cl2FN2O7S/c1-32(42,21-9-13-45-14-10-21)23-15-26-29(27(37)16-23)34(22-4-7-24(35)8-5-22,46-19-33(11-12-33)31(38)41)39(30(26)40)18-20-3-6-25(36)17-28(20)47(2,43)44/h3-8,15-17,21,42H,9-14,18-19H2,1-2H3,(H2,38,41)/t32-,34-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.490	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10544132 (2020) BindingDB Entry DOI: 10.7270/Q27H1N06
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM427143 (1-({[(1R)-2-[(4-chloro-2-methanesulfonylphenyl)met...) Show SMILES C[C@@](O)(C1CCOCC1)c1cc2C(=O)N(Cc3ccc(Cl)cc3S(C)(=O)=O)[C@](OCC3(CC3)C(N)=O)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C34H35Cl2FN2O7S/c1-32(42,21-9-13-45-14-10-21)23-15-26-29(27(37)16-23)34(22-4-7-24(35)8-5-22,46-19-33(11-12-33)31(38)41)39(30(26)40)18-20-3-6-25(36)17-28(20)47(2,43)44/h3-8,15-17,21,42H,9-14,18-19H2,1-2H3,(H2,38,41)/t32-,34-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.490	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10981898 (2021) BindingDB Entry DOI: 10.7270/Q2154M5V
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM427127 (1-({[(1R)-2-[(4-chloro-2-methanesulfonylphenyl)met...) Show SMILES Cn1cc(cn1)[C@](C)(O)c1cc2C(=O)N(Cc3ccc(Cl)cc3S(C)(=O)=O)[C@](OCC3(CC3)C(N)=O)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C33H31Cl2FN4O6S/c1-31(43,22-15-38-39(2)17-22)21-12-25-28(26(36)13-21)33(20-5-8-23(34)9-6-20,46-18-32(10-11-32)30(37)42)40(29(25)41)16-19-4-7-24(35)14-27(19)47(3,44)45/h4-9,12-15,17,43H,10-11,16,18H2,1-3H3,(H2,37,42)/t31-,33-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10544132 (2020) BindingDB Entry DOI: 10.7270/Q27H1N06
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM427127 (1-({[(1R)-2-[(4-chloro-2-methanesulfonylphenyl)met...) Show SMILES Cn1cc(cn1)[C@](C)(O)c1cc2C(=O)N(Cc3ccc(Cl)cc3S(C)(=O)=O)[C@](OCC3(CC3)C(N)=O)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C33H31Cl2FN4O6S/c1-31(43,22-15-38-39(2)17-22)21-12-25-28(26(36)13-21)33(20-5-8-23(34)9-6-20,46-18-32(10-11-32)30(37)42)40(29(25)41)16-19-4-7-24(35)14-27(19)47(3,44)45/h4-9,12-15,17,43H,10-11,16,18H2,1-3H3,(H2,37,42)/t31-,33-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10981898 (2021) BindingDB Entry DOI: 10.7270/Q2154M5V
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM427196 (US10544132, Example 137) Show SMILES CC[C@](O)(C1CCN(CCC(O)=O)CC1)c1cc2C(=O)N(Cc3ccc(Cl)cc3)C(OC)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C33H35Cl2FN2O5/c1-3-32(42,22-12-15-37(16-13-22)17-14-29(39)40)24-18-27-30(28(36)19-24)33(43-2,23-6-10-26(35)11-7-23)38(31(27)41)20-21-4-8-25(34)9-5-21/h4-11,18-19,22,42H,3,12-17,20H2,1-2H3,(H,39,40)/t32-,33?/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.570	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10544132 (2020) BindingDB Entry DOI: 10.7270/Q27H1N06
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM427195 (US10544132, Example 136 | US10981898, Example 137 ...) Show SMILES CC[C@](O)(C1CCN(CCC(=O)OC)CC1)c1cc2C(=O)N(Cc3ccc(Cl)cc3)[C@](OC)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C34H37Cl2FN2O5/c1-4-33(42,23-13-16-38(17-14-23)18-15-30(40)43-2)25-19-28-31(29(37)20-25)34(44-3,24-7-11-27(36)12-8-24)39(32(28)41)21-22-5-9-26(35)10-6-22/h5-12,19-20,23,42H,4,13-18,21H2,1-3H3/t33-,34+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.570	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10981898 (2021) BindingDB Entry DOI: 10.7270/Q2154M5V
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM427156 (4-{[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[I-hydroxy-...) Show SMILES CC[C@@](O)(c1cn(C)cn1)c1cc2C(=O)N(Cc3ccc(cc3)C#N)[C@](O[C@H]3CCOC3)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C33H30ClFN4O4/c1-3-32(41,29-18-38(2)20-37-29)24-14-27-30(28(35)15-24)33(43-26-12-13-42-19-26,23-8-10-25(34)11-9-23)39(31(27)40)17-22-6-4-21(16-36)5-7-22/h4-11,14-15,18,20,26,41H,3,12-13,17,19H2,1-2H3/t26-,32-,33+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.640	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10981898 (2021) BindingDB Entry DOI: 10.7270/Q2154M5V
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM427156 (4-{[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[I-hydroxy-...) Show SMILES CC[C@@](O)(c1cn(C)cn1)c1cc2C(=O)N(Cc3ccc(cc3)C#N)[C@](O[C@H]3CCOC3)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C33H30ClFN4O4/c1-3-32(41,29-18-38(2)20-37-29)24-14-27-30(28(35)15-24)33(43-26-12-13-42-19-26,23-8-10-25(34)11-9-23)39(31(27)40)17-22-6-4-21(16-36)5-7-22/h4-11,14-15,18,20,26,41H,3,12-13,17,19H2,1-2H3/t26-,32-,33+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.640	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10544132 (2020) BindingDB Entry DOI: 10.7270/Q27H1N06
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM427123 (US10544132, Example 70 | US10981898, Example 69) Show SMILES CN1CCN(C[C@@](C)(O)c2cc3C(=O)N(Cc4ccc(Cl)cc4S(C)(=O)=O)[C@](O[C@H]4CCOC4)(c3c(F)c2)c2ccc(Cl)cc2)CC1 |r| Show InChI InChI=1S/C34H38Cl2FN3O6S/c1-33(42,21-39-13-11-38(2)12-14-39)24-16-28-31(29(37)17-24)34(46-27-10-15-45-20-27,23-5-8-25(35)9-6-23)40(32(28)41)19-22-4-7-26(36)18-30(22)47(3,43)44/h4-9,16-18,27,42H,10-15,19-21H2,1-3H3/t27-,33+,34+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10981898 (2021) BindingDB Entry DOI: 10.7270/Q2154M5V
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM427122 (US10544132, Example 69 | US10981898, Example 70) Show SMILES CN1CCN(C[C@](C)(O)c2cc3C(=O)N(Cc4ccc(Cl)cc4S(C)(=O)=O)[C@](O[C@H]4CCOC4)(c3c(F)c2)c2ccc(Cl)cc2)CC1 |r| Show InChI InChI=1S/C34H38Cl2FN3O6S/c1-33(42,21-39-13-11-38(2)12-14-39)24-16-28-31(29(37)17-24)34(46-27-10-15-45-20-27,23-5-8-25(35)9-6-23)40(32(28)41)19-22-4-7-26(36)18-30(22)47(3,43)44/h4-9,16-18,27,42H,10-15,19-21H2,1-3H3/t27-,33-,34+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10544132 (2020) BindingDB Entry DOI: 10.7270/Q27H1N06
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM427147 ((3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)...) Show SMILES CO[C@]1(N([C@@H](CC(O)=O)c2ccc(Cl)cc2)C(=O)c2cc(cc(F)c12)[C@@](C)(O)C1CCOCC1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C31H30Cl2FNO6/c1-30(39,19-11-13-41-14-12-19)21-15-24-28(25(34)16-21)31(40-2,20-5-9-23(33)10-6-20)35(29(24)38)26(17-27(36)37)18-3-7-22(32)8-4-18/h3-10,15-16,19,26,39H,11-14,17H2,1-2H3,(H,36,37)/t26-,30-,31+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.790	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10981898 (2021) BindingDB Entry DOI: 10.7270/Q2154M5V
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM427147 ((3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)...) Show SMILES CO[C@]1(N([C@@H](CC(O)=O)c2ccc(Cl)cc2)C(=O)c2cc(cc(F)c12)[C@@](C)(O)C1CCOCC1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C31H30Cl2FNO6/c1-30(39,19-11-13-41-14-12-19)21-15-24-28(25(34)16-21)31(40-2,20-5-9-23(33)10-6-20)35(29(24)38)26(17-27(36)37)18-3-7-22(32)8-4-18/h3-10,15-16,19,26,39H,11-14,17H2,1-2H3,(H,36,37)/t26-,30-,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.790	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10544132 (2020) BindingDB Entry DOI: 10.7270/Q27H1N06
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM492987 (US10981898, Example 98) Show SMILES CO[C@]1(N([C@@H](CC(O)=O)c2ccc(Cl)cc2)C(=O)c2cc(cc(F)c12)[C@](C)(O)C1(F)CCOCC1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C31H29Cl2F2NO6/c1-29(40,30(35)11-13-42-14-12-30)20-15-23-27(24(34)16-20)31(41-2,19-5-9-22(33)10-6-19)36(28(23)39)25(17-26(37)38)18-3-7-21(32)8-4-18/h3-10,15-16,25,40H,11-14,17H2,1-2H3,(H,37,38)/t25-,29-,31+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10981898 (2021) BindingDB Entry DOI: 10.7270/Q2154M5V
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM427158 ((3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)...) Show SMILES CO[C@]1(N([C@H](CC(O)=O)c2ccc(Cl)cc2)C(=O)c2cc(cc(F)c12)[C@](C)(O)C1(F)CCOCC1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C31H29Cl2F2NO6/c1-29(40,30(35)11-13-42-14-12-30)20-15-23-27(24(34)16-20)31(41-2,19-5-9-22(33)10-6-19)36(28(23)39)25(17-26(37)38)18-3-7-21(32)8-4-18/h3-10,15-16,25,40H,11-14,17H2,1-2H3,(H,37,38)/t25-,29+,31-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10544132 (2020) BindingDB Entry DOI: 10.7270/Q27H1N06
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM427098 (US10544132, Example 50 | US10981898, Example 62 | ...) Show SMILES CC(C)(O)c1cc2C(=O)N(Cc3ccc(Cl)cc3S(C)(=O)=O)[C@](OCC3(CO)CC3)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C30H30Cl2FNO6S/c1-28(2,37)20-12-23-26(24(33)13-20)30(19-5-8-21(31)9-6-19,40-17-29(16-35)10-11-29)34(27(23)36)15-18-4-7-22(32)14-25(18)41(3,38)39/h4-9,12-14,35,37H,10-11,15-17H2,1-3H3/t30-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10544132 (2020) BindingDB Entry DOI: 10.7270/Q27H1N06
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM427098 (US10544132, Example 50 | US10981898, Example 62 | ...) Show SMILES CC(C)(O)c1cc2C(=O)N(Cc3ccc(Cl)cc3S(C)(=O)=O)[C@](OCC3(CO)CC3)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C30H30Cl2FNO6S/c1-28(2,37)20-12-23-26(24(33)13-20)30(19-5-8-21(31)9-6-19,40-17-29(16-35)10-11-29)34(27(23)36)15-18-4-7-22(32)14-25(18)41(3,38)39/h4-9,12-14,35,37H,10-11,15-17H2,1-3H3/t30-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10981898 (2021) BindingDB Entry DOI: 10.7270/Q2154M5V
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM427136 ((3R)-2-[(4-chloro-2-methanesulfonylphenyl)methyl]-...) Show SMILES CS(=O)(=O)c1cc(Cl)ccc1CN1C(=O)c2cc(cc(F)c2[C@]1(OCC1(CO)CC1)c1ccc(Cl)cc1)[C@@H](O)C1CCOCC1 |r| Show InChI InChI=1S/C33H34Cl2FNO7S/c1-45(41,42)28-16-25(35)5-2-21(28)17-37-31(40)26-14-22(30(39)20-8-12-43-13-9-20)15-27(36)29(26)33(37,23-3-6-24(34)7-4-23)44-19-32(18-38)10-11-32/h2-7,14-16,20,30,38-39H,8-13,17-19H2,1H3/t30-,33+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10544132 (2020) BindingDB Entry DOI: 10.7270/Q27H1N06
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM427139 ((3R)-2-[(4-chloro-2-methanesulfonylphenyl)methyl]-...) Show SMILES CS(=O)(=O)c1cc(Cl)ccc1CN1C(=O)c2cc(cc(F)c2[C@]1(OCC1(CO)CC1)c1ccc(Cl)cc1)[C@H](O)C1CCOCC1 |r| Show InChI InChI=1S/C33H34Cl2FNO7S/c1-45(41,42)28-16-25(35)5-2-21(28)17-37-31(40)26-14-22(30(39)20-8-12-43-13-9-20)15-27(36)29(26)33(37,23-3-6-24(34)7-4-23)44-19-32(18-38)10-11-32/h2-7,14-16,20,30,38-39H,8-13,17-19H2,1H3/t30-,33-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10981898 (2021) BindingDB Entry DOI: 10.7270/Q2154M5V
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM427193 (US10544132, Example 134 | US11236047, Example 135) Show SMILES CC[C@@](O)(C1CCN(CC(O)=O)CC1)c1cc2C(=O)N(Cc3ccc(Cl)cc3)[C@](OC)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C32H33Cl2FN2O5/c1-3-31(41,21-12-14-36(15-13-21)19-28(38)39)23-16-26-29(27(35)17-23)32(42-2,22-6-10-25(34)11-7-22)37(30(26)40)18-20-4-8-24(33)9-5-20/h4-11,16-17,21,41H,3,12-15,18-19H2,1-2H3,(H,38,39)/t31-,32-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10544132 (2020) BindingDB Entry DOI: 10.7270/Q27H1N06
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM427194 (US10544132, Example 135 | US10981898, Example 134 ...) Show SMILES CC[C@](O)(C1CCN(CC(O)=O)CC1)c1cc2C(=O)N(Cc3ccc(Cl)cc3)[C@](OC)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C32H33Cl2FN2O5/c1-3-31(41,21-12-14-36(15-13-21)19-28(38)39)23-16-26-29(27(35)17-23)32(42-2,22-6-10-25(34)11-7-22)37(30(26)40)18-20-4-8-24(33)9-5-20/h4-11,16-17,21,41H,3,12-15,18-19H2,1-2H3,(H,38,39)/t31-,32+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10981898 (2021) BindingDB Entry DOI: 10.7270/Q2154M5V
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM427195 (US10544132, Example 136 | US10981898, Example 137 ...) Show SMILES CC[C@](O)(C1CCN(CCC(=O)OC)CC1)c1cc2C(=O)N(Cc3ccc(Cl)cc3)[C@](OC)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C34H37Cl2FN2O5/c1-4-33(42,23-13-16-38(17-14-23)18-15-30(40)43-2)25-19-28-31(29(37)20-25)34(44-3,24-7-11-27(36)12-8-24)39(32(28)41)21-22-5-9-26(35)10-6-22/h5-12,19-20,23,42H,4,13-18,21H2,1-3H3/t33-,34+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10981898 (2021) BindingDB Entry DOI: 10.7270/Q2154M5V
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM427195 (US10544132, Example 136 | US10981898, Example 137 ...) Show SMILES CC[C@](O)(C1CCN(CCC(=O)OC)CC1)c1cc2C(=O)N(Cc3ccc(Cl)cc3)[C@](OC)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C34H37Cl2FN2O5/c1-4-33(42,23-13-16-38(17-14-23)18-15-30(40)43-2)25-19-28-31(29(37)20-25)34(44-3,24-7-11-27(36)12-8-24)39(32(28)41)21-22-5-9-26(35)10-6-22/h5-12,19-20,23,42H,4,13-18,21H2,1-3H3/t33-,34+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10544132 (2020) BindingDB Entry DOI: 10.7270/Q27H1N06
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM427125 (US10544132, Example 72 | US10981898, Example 72 | ...) Show SMILES CC(C)(O)c1cc2C(=O)N(Cc3ccc(Cl)cc3CO)[C@](OCC3(CC3)C#N)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C30H27Cl2FN2O4/c1-28(2,38)21-12-24-26(25(33)13-21)30(20-4-7-22(31)8-5-20,39-17-29(16-34)9-10-29)35(27(24)37)14-18-3-6-23(32)11-19(18)15-36/h3-8,11-13,36,38H,9-10,14-15,17H2,1-2H3/t30-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10981898 (2021) BindingDB Entry DOI: 10.7270/Q2154M5V
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM427125 (US10544132, Example 72 | US10981898, Example 72 | ...) Show SMILES CC(C)(O)c1cc2C(=O)N(Cc3ccc(Cl)cc3CO)[C@](OCC3(CC3)C#N)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C30H27Cl2FN2O4/c1-28(2,38)21-12-24-26(25(33)13-21)30(20-4-7-22(31)8-5-20,39-17-29(16-34)9-10-29)35(27(24)37)14-18-3-6-23(32)11-19(18)15-36/h3-8,11-13,36,38H,9-10,14-15,17H2,1-2H3/t30-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10544132 (2020) BindingDB Entry DOI: 10.7270/Q27H1N06
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM427086 ((3R)-2-[(4-chloro-2-methanesulfonylphenyl)methyl]-...) Show SMILES C[C@@](O)(C1CCOCC1)c1cc2C(=O)N(Cc3ccc(Cl)cc3S(C)(=O)=O)[C@](OCC3(CO)CC3)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C34H36Cl2FNO7S/c1-32(41,22-9-13-44-14-10-22)24-15-27-30(28(37)16-24)34(23-4-7-25(35)8-5-23,45-20-33(19-39)11-12-33)38(31(27)40)18-21-3-6-26(36)17-29(21)46(2,42)43/h3-8,15-17,22,39,41H,9-14,18-20H2,1-2H3/t32-,34-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10981898 (2021) BindingDB Entry DOI: 10.7270/Q2154M5V
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM427086 ((3R)-2-[(4-chloro-2-methanesulfonylphenyl)methyl]-...) Show SMILES C[C@@](O)(C1CCOCC1)c1cc2C(=O)N(Cc3ccc(Cl)cc3S(C)(=O)=O)[C@](OCC3(CO)CC3)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C34H36Cl2FNO7S/c1-32(41,22-9-13-44-14-10-22)24-15-27-30(28(37)16-24)34(23-4-7-25(35)8-5-23,45-20-33(19-39)11-12-33)38(31(27)40)18-21-3-6-26(36)17-29(21)46(2,42)43/h3-8,15-17,22,39,41H,9-14,18-20H2,1-2H3/t32-,34-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10544132 (2020) BindingDB Entry DOI: 10.7270/Q27H1N06
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM492940 (US10981898, Example 35 | US11236047, Example 35 | ...) Show SMILES CC(C)(O)c1cc2C(=O)N(Cc3ccc(Cl)cc3S(C)(=O)=O)[C@](OCC3(CC3)C(N)=O)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C30H29Cl2FN2O6S/c1-28(2,38)19-12-22-25(23(33)13-19)30(18-5-8-20(31)9-6-18,41-16-29(10-11-29)27(34)37)35(26(22)36)15-17-4-7-21(32)14-24(17)42(3,39)40/h4-9,12-14,38H,10-11,15-16H2,1-3H3,(H2,34,37)/t30-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10981898 (2021) BindingDB Entry DOI: 10.7270/Q2154M5V
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM427118 ((3R)-2-[(4-Chloro-2-methanesulfonylphenyl)methyl]-...) Show SMILES C[C@@](O)(CO)c1cc2C(=O)N(Cc3ccc(Cl)cc3S(C)(=O)=O)[C@](OCC3(CO)CC3)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C30H30Cl2FNO7S/c1-28(38,15-35)20-11-23-26(24(33)12-20)30(19-4-7-21(31)8-5-19,41-17-29(16-36)9-10-29)34(27(23)37)14-18-3-6-22(32)13-25(18)42(2,39)40/h3-8,11-13,35-36,38H,9-10,14-17H2,1-2H3/t28-,30-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10544132 (2020) BindingDB Entry DOI: 10.7270/Q27H1N06
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM427080 (US10544132, Example 35) Show SMILES CC(C)(O)c1cc2C(=O)N(Cc3ccc(Cl)cc3S(C)(=O)=O)C(OCC3(CC3)C(N)=O)(c2c(F)c1)c1ccc(Cl)cc1 Show InChI InChI=1S/C30H29Cl2FN2O6S/c1-28(2,38)19-12-22-25(23(33)13-19)30(18-5-8-20(31)9-6-18,41-16-29(10-11-29)27(34)37)35(26(22)36)15-17-4-7-21(32)14-24(17)42(3,39)40/h4-9,12-14,38H,10-11,15-16H2,1-3H3,(H2,34,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10544132 (2020) BindingDB Entry DOI: 10.7270/Q27H1N06
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM427118 ((3R)-2-[(4-Chloro-2-methanesulfonylphenyl)methyl]-...) Show SMILES C[C@@](O)(CO)c1cc2C(=O)N(Cc3ccc(Cl)cc3S(C)(=O)=O)[C@](OCC3(CO)CC3)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C30H30Cl2FNO7S/c1-28(38,15-35)20-11-23-26(24(33)12-20)30(19-4-7-21(31)8-5-19,41-17-29(16-36)9-10-29)34(27(23)37)14-18-3-6-22(32)13-25(18)42(2,39)40/h3-8,11-13,35-36,38H,9-10,14-17H2,1-2H3/t28-,30-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10981898 (2021) BindingDB Entry DOI: 10.7270/Q2154M5V
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM427185 (US10544132, Example 126) Show SMILES CC[C@@](C)(O)c1cc2C(=O)N([C@@H](CC(O)=O)c3ccc(Cl)cc3)[C@](OCC3(F)COC3)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C31H29Cl2F2NO6/c1-3-29(2,40)20-12-23-27(24(34)13-20)31(19-6-10-22(33)11-7-19,42-17-30(35)15-41-16-30)36(28(23)39)25(14-26(37)38)18-4-8-21(32)9-5-18/h4-13,25,40H,3,14-17H2,1-2H3,(H,37,38)/t25-,29+,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10544132 (2020) BindingDB Entry DOI: 10.7270/Q27H1N06
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM427081 ( (3R)-2-[(4-chloro-2-methanesulfonylphenyl)methyl]...) Show SMILES CC(C)(O)c1ccc2c(c1)C(=O)N(Cc1ccc(Cl)cc1S(C)(=O)=O)[C@@]2(OCC1(CO)CC1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C30H31Cl2NO6S/c1-28(2,36)21-7-11-25-24(14-21)27(35)33(16-19-4-8-23(32)15-26(19)40(3,37)38)30(25,20-5-9-22(31)10-6-20)39-18-29(17-34)12-13-29/h4-11,14-15,34,36H,12-13,16-18H2,1-3H3/t30-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10981898 (2021) BindingDB Entry DOI: 10.7270/Q2154M5V
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM427078 (US10544132, Example 33 | US11236047, Example 33 | ...) Show SMILES CC(C)(O)c1ccc2c(c1)C(=O)N(Cc1ccc(Cl)cc1C(O)=O)[C@@]2(OCC1(CO)CC1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C30H29Cl2NO6/c1-28(2,38)20-6-10-25-24(13-20)26(35)33(15-18-3-7-22(32)14-23(18)27(36)37)30(25,19-4-8-21(31)9-5-19)39-17-29(16-34)11-12-29/h3-10,13-14,34,38H,11-12,15-17H2,1-2H3,(H,36,37)/t30-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10544132 (2020) BindingDB Entry DOI: 10.7270/Q27H1N06
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM492938 (US10981898, Example 33) Show SMILES CC(=O)c1ccc2c(c1)C(=O)N(Cc1ccc(Cl)cc1Br)C2(O)c1ccc(Cl)cc1 Show InChI InChI=1S/C23H16BrCl2NO3/c1-13(28)14-3-9-20-19(10-14)22(29)27(12-15-2-6-18(26)11-21(15)24)23(20,30)16-4-7-17(25)8-5-16/h2-11,30H,12H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10981898 (2021) BindingDB Entry DOI: 10.7270/Q2154M5V
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM427184 (US10544132, Example 125 | US10981898, Example 126) Show SMILES CC[C@](C)(O)c1cc2C(=O)N([C@@H](CC(O)=O)c3ccc(Cl)cc3)[C@](OCC3(F)COC3)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C31H29Cl2F2NO6/c1-3-29(2,40)20-12-23-27(24(34)13-20)31(19-6-10-22(33)11-7-19,42-17-30(35)15-41-16-30)36(28(23)39)25(14-26(37)38)18-4-8-21(32)9-5-18/h4-13,25,40H,3,14-17H2,1-2H3,(H,37,38)/t25-,29-,31+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10981898 (2021) BindingDB Entry DOI: 10.7270/Q2154M5V
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM427081 ( (3R)-2-[(4-chloro-2-methanesulfonylphenyl)methyl]...) Show SMILES CC(C)(O)c1ccc2c(c1)C(=O)N(Cc1ccc(Cl)cc1S(C)(=O)=O)[C@@]2(OCC1(CO)CC1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C30H31Cl2NO6S/c1-28(2,36)21-7-11-25-24(14-21)27(35)33(16-19-4-8-23(32)15-26(19)40(3,37)38)30(25,20-5-9-22(31)10-6-20)39-18-29(17-34)12-13-29/h4-11,14-15,34,36H,12-13,16-18H2,1-3H3/t30-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10544132 (2020) BindingDB Entry DOI: 10.7270/Q27H1N06
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM427124 (US10544132, Example 71 | US10981898, Example 71 | ...) Show SMILES CC(C)(O)c1cc2C(=O)N([C@@H](CC(O)=O)c3ccc(Cl)cc3)[C@](O[C@H]3CCOC3)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C30H28Cl2FNO6/c1-29(2,38)19-13-23-27(24(33)14-19)30(40-22-11-12-39-16-22,18-5-9-21(32)10-6-18)34(28(23)37)25(15-26(35)36)17-3-7-20(31)8-4-17/h3-10,13-14,22,25,38H,11-12,15-16H2,1-2H3,(H,35,36)/t22-,25-,30+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10544132 (2020) BindingDB Entry DOI: 10.7270/Q27H1N06
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM427124 (US10544132, Example 71 | US10981898, Example 71 | ...) Show SMILES CC(C)(O)c1cc2C(=O)N([C@@H](CC(O)=O)c3ccc(Cl)cc3)[C@](O[C@H]3CCOC3)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C30H28Cl2FNO6/c1-29(2,38)19-13-23-27(24(33)14-19)30(40-22-11-12-39-16-22,18-5-9-21(32)10-6-18)34(28(23)37)25(15-26(35)36)17-3-7-20(31)8-4-17/h3-10,13-14,22,25,38H,11-12,15-16H2,1-2H3,(H,35,36)/t22-,25-,30+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10981898 (2021) BindingDB Entry DOI: 10.7270/Q2154M5V
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM427117 ((3R)-2-[(4-Chloro-2-methanesulfonylphenyl)methyl]-...) Show SMILES COC[C@](C)(O)c1cc2C(=O)N(Cc3ccc(Cl)cc3S(C)(=O)=O)[C@](OCC3(CO)CC3)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C31H32Cl2FNO7S/c1-29(38,17-41-2)21-12-24-27(25(34)13-21)31(20-5-8-22(32)9-6-20,42-18-30(16-36)10-11-30)35(28(24)37)15-19-4-7-23(33)14-26(19)43(3,39)40/h4-9,12-14,36,38H,10-11,15-18H2,1-3H3/t29-,31+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10544132 (2020) BindingDB Entry DOI: 10.7270/Q27H1N06
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM427116 ((3R)-2-[(4-Chloro-2-methanesulfonylphenyl)methyl]-...) Show SMILES COC[C@@](C)(O)c1cc2C(=O)N(Cc3ccc(Cl)cc3S(C)(=O)=O)[C@](OCC3(CO)CC3)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C31H32Cl2FNO7S/c1-29(38,17-41-2)21-12-24-27(25(34)13-21)31(20-5-8-22(32)9-6-20,42-18-30(16-36)10-11-30)35(28(24)37)15-19-4-7-23(33)14-26(19)43(3,39)40/h4-9,12-14,36,38H,10-11,15-18H2,1-3H3/t29-,31-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10981898 (2021) BindingDB Entry DOI: 10.7270/Q2154M5V
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM427132 (US10544132, Example 79 | US11236047, Example 79 | ...) Show SMILES CC(C)(O)c1cc2C(=O)N(Cc3ccc(Cl)cc3C(O)=O)[C@](OCC3(CC3)C#N)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C30H25Cl2FN2O5/c1-28(2,39)19-11-23-25(24(33)12-19)30(18-4-7-20(31)8-5-18,40-16-29(15-34)9-10-29)35(26(23)36)14-17-3-6-21(32)13-22(17)27(37)38/h3-8,11-13,39H,9-10,14,16H2,1-2H3,(H,37,38)/t30-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10544132 (2020) BindingDB Entry DOI: 10.7270/Q27H1N06
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM492977 (US10981898, Example 79) Show SMILES CC(C)(O)c1cc2C(=O)N(Cc3ccc(Cl)cc3Br)[C@](OCC3(CC3)C#N)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C29H24BrCl2FN2O3/c1-27(2,37)19-11-22-25(24(33)12-19)29(18-4-7-20(31)8-5-18,38-16-28(15-34)9-10-28)35(26(22)36)14-17-3-6-21(32)13-23(17)30/h3-8,11-13,37H,9-10,14,16H2,1-2H3/t29-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10981898 (2021) BindingDB Entry DOI: 10.7270/Q2154M5V
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM427115 ((3R)-2-[(4-Chloro-2-methanesulfinylphenyl)methyl]-...) Show SMILES C[S@@](=O)c1cc(Cl)ccc1CN1C(=O)c2cc(cc(F)c2[C@]1(OCC1(CO)CC1)c1ccc(Cl)cc1)C(C)(C)O |r| Show InChI InChI=1S/C30H30Cl2FNO5S/c1-28(2,37)20-12-23-26(24(33)13-20)30(19-5-8-21(31)9-6-19,39-17-29(16-35)10-11-29)34(27(23)36)15-18-4-7-22(32)14-25(18)40(3)38/h4-9,12-14,35,37H,10-11,15-17H2,1-3H3/t30-,40-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10544132 (2020) BindingDB Entry DOI: 10.7270/Q27H1N06
					More data for this Ligand-Target Pair
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188] (Homo sapiens (Human))	BDBM427098 (US10544132, Example 50 | US10981898, Example 62 | ...) Show SMILES CC(C)(O)c1cc2C(=O)N(Cc3ccc(Cl)cc3S(C)(=O)=O)[C@](OCC3(CO)CC3)(c2c(F)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C30H30Cl2FNO6S/c1-28(2,37)20-12-23-26(24(33)13-20)30(19-5-8-21(31)9-6-19,40-17-29(16-35)10-11-29)34(27(23)36)15-18-4-7-22(32)14-25(18)41(3,38)39/h4-9,12-14,35,37H,10-11,15-17H2,1-3H3/t30-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED US Patent					Assay Description The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...				US Patent US10981898 (2021) BindingDB Entry DOI: 10.7270/Q2154M5V
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 1 (Homo sapiens (Human))	BDBM50195239 (CHEMBL3972563 | US10287258, Example 29 | US1066924...) Show SMILES Cn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| Show InChI InChI=1S/C23H24N4O3S/c1-27-19-12-17(7-8-21(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)20-14-25-9-2-10-30-20/h3-8,12,18,20,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,20-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2FB56W4
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 1 (Homo sapiens (Human))	BDBM50195239 (CHEMBL3972563 | US10287258, Example 29 | US1066924...) Show SMILES Cn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| Show InChI InChI=1S/C23H24N4O3S/c1-27-19-12-17(7-8-21(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)20-14-25-9-2-10-30-20/h3-8,12,18,20,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,20-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
ASTRAZENECA AB US Patent					Assay Description The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic...				US Patent US10669245 (2020) BindingDB Entry DOI: 10.7270/Q2862KG7
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 1 (Homo sapiens (Human))	BDBM50195239 (CHEMBL3972563 | US10287258, Example 29 | US1066924...) Show SMILES Cn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| Show InChI InChI=1S/C23H24N4O3S/c1-27-19-12-17(7-8-21(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)20-14-25-9-2-10-30-20/h3-8,12,18,20,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,20-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q24X5CXQ
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 1 (Homo sapiens (Human))	BDBM50195239 (CHEMBL3972563 | US10287258, Example 29 | US1066924...) Show SMILES Cn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| Show InChI InChI=1S/C23H24N4O3S/c1-27-19-12-17(7-8-21(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)20-14-25-9-2-10-30-20/h3-8,12,18,20,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,20-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Examples 1-35: The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly...				Citation and Details BindingDB Entry DOI: 10.7270/Q2Q243DZ
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 1 (Homo sapiens (Human))	BDBM50195239 (CHEMBL3972563 | US10287258, Example 29 | US1066924...) Show SMILES Cn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| Show InChI InChI=1S/C23H24N4O3S/c1-27-19-12-17(7-8-21(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)20-14-25-9-2-10-30-20/h3-8,12,18,20,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,20-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2ZG6X5T
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 1 (Homo sapiens (Human))	BDBM604873 ((2S)-N-[(1S)-1-Cyano-2-[4-(3-methyl-2-oxo-2,3-dihy...) Show SMILES Cn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2H99949
					More data for this Ligand-Target Pair

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