Found 297 hits with Last Name = 'jones' and Initial = 'gp' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50195239
(CHEMBL3972563 | US10287258, Example 29 | US1066924...)Show SMILES Cn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| Show InChI InChI=1S/C23H24N4O3S/c1-27-19-12-17(7-8-21(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)20-14-25-9-2-10-30-20/h3-8,12,18,20,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,20-/m0/s1 | PDB
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| CHEMBL
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UniChem
Similars
| | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2F76HN2 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50195239
(CHEMBL3972563 | US10287258, Example 29 | US1066924...)Show SMILES Cn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| Show InChI InChI=1S/C23H24N4O3S/c1-27-19-12-17(7-8-21(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)20-14-25-9-2-10-30-20/h3-8,12,18,20,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,20-/m0/s1 | PDB
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| CHEMBL
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UniChem
Similars
| US Patent
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description
The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic... |
J Med Chem 51: 7049-52 (2008)
BindingDB Entry DOI: 10.7270/Q2RJ4MTP |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50195239
(CHEMBL3972563 | US10287258, Example 29 | US1066924...)Show SMILES Cn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| Show InChI InChI=1S/C23H24N4O3S/c1-27-19-12-17(7-8-21(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)20-14-25-9-2-10-30-20/h3-8,12,18,20,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,20-/m0/s1 | PDB
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| | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2FB56W4 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50195239
(CHEMBL3972563 | US10287258, Example 29 | US1066924...)Show SMILES Cn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| Show InChI InChI=1S/C23H24N4O3S/c1-27-19-12-17(7-8-21(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)20-14-25-9-2-10-30-20/h3-8,12,18,20,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,20-/m0/s1 | PDB
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TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2ZG6X5T |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50195239
(CHEMBL3972563 | US10287258, Example 29 | US1066924...)Show SMILES Cn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| Show InChI InChI=1S/C23H24N4O3S/c1-27-19-12-17(7-8-21(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)20-14-25-9-2-10-30-20/h3-8,12,18,20,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,20-/m0/s1 | PDB
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| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Examples 1-35: The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2Q243DZ |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50195239
(CHEMBL3972563 | US10287258, Example 29 | US1066924...)Show SMILES Cn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| Show InChI InChI=1S/C23H24N4O3S/c1-27-19-12-17(7-8-21(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)20-14-25-9-2-10-30-20/h3-8,12,18,20,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,20-/m0/s1 | PDB
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TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24X5CXQ |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM604873
((2S)-N-[(1S)-1-Cyano-2-[4-(3-methyl-2-oxo-2,3-dihy...)Show SMILES Cn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 | PDB
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TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2H99949 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50195239
(CHEMBL3972563 | US10287258, Example 29 | US1066924...)Show SMILES Cn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| Show InChI InChI=1S/C23H24N4O3S/c1-27-19-12-17(7-8-21(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)20-14-25-9-2-10-30-20/h3-8,12,18,20,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,20-/m0/s1 | PDB
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ASTRAZENECA AB
US Patent
| Assay Description
The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic... |
US Patent US10669245 (2020)
BindingDB Entry DOI: 10.7270/Q2862KG7 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385058
((2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-methoxyethyl)-2-ox...)Show SMILES COCCn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 Show InChI InChI=1S/C25H28N4O4S/c1-32-12-10-29-21-14-19(7-8-23(21)34-25(29)31)18-5-3-17(4-6-18)13-20(15-26)28-24(30)22-16-27-9-2-11-33-22/h3-8,14,20,22,27H,2,9-13,16H2,1H3,(H,28,30)/t20-,22-/m0/s1 | PDB
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| | n/a | n/a | 3.16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2F76HN2 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385058
((2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-methoxyethyl)-2-ox...)Show SMILES COCCn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 Show InChI InChI=1S/C25H28N4O4S/c1-32-12-10-29-21-14-19(7-8-23(21)34-25(29)31)18-5-3-17(4-6-18)13-20(15-26)28-24(30)22-16-27-9-2-11-33-22/h3-8,14,20,22,27H,2,9-13,16H2,1H3,(H,28,30)/t20-,22-/m0/s1 | PDB
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| PC cid
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| US Patent
| n/a | n/a | 3.16 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis
| Assay Description
The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic... |
J Med Chem 51: 7049-52 (2008)
BindingDB Entry DOI: 10.7270/Q2RJ4MTP |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385058
((2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-methoxyethyl)-2-ox...)Show SMILES COCCn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 Show InChI InChI=1S/C25H28N4O4S/c1-32-12-10-29-21-14-19(7-8-23(21)34-25(29)31)18-5-3-17(4-6-18)13-20(15-26)28-24(30)22-16-27-9-2-11-33-22/h3-8,14,20,22,27H,2,9-13,16H2,1H3,(H,28,30)/t20-,22-/m0/s1 | PDB
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TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2FB56W4 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385058
((2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-methoxyethyl)-2-ox...)Show SMILES COCCn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 Show InChI InChI=1S/C25H28N4O4S/c1-32-12-10-29-21-14-19(7-8-23(21)34-25(29)31)18-5-3-17(4-6-18)13-20(15-26)28-24(30)22-16-27-9-2-11-33-22/h3-8,14,20,22,27H,2,9-13,16H2,1H3,(H,28,30)/t20-,22-/m0/s1 | PDB
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TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2ZG6X5T |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385058
((2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-methoxyethyl)-2-ox...)Show SMILES COCCn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 Show InChI InChI=1S/C25H28N4O4S/c1-32-12-10-29-21-14-19(7-8-23(21)34-25(29)31)18-5-3-17(4-6-18)13-20(15-26)28-24(30)22-16-27-9-2-11-33-22/h3-8,14,20,22,27H,2,9-13,16H2,1H3,(H,28,30)/t20-,22-/m0/s1 | PDB
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| PC cid
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| US Patent
| n/a | n/a | 3.16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Examples 1-35: The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2Q243DZ |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385058
((2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-methoxyethyl)-2-ox...)Show SMILES COCCn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 Show InChI InChI=1S/C25H28N4O4S/c1-32-12-10-29-21-14-19(7-8-23(21)34-25(29)31)18-5-3-17(4-6-18)13-20(15-26)28-24(30)22-16-27-9-2-11-33-22/h3-8,14,20,22,27H,2,9-13,16H2,1H3,(H,28,30)/t20-,22-/m0/s1 | PDB
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TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24X5CXQ |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385058
((2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-methoxyethyl)-2-ox...)Show SMILES COCCn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 Show InChI InChI=1S/C25H28N4O4S/c1-32-12-10-29-21-14-19(7-8-23(21)34-25(29)31)18-5-3-17(4-6-18)13-20(15-26)28-24(30)22-16-27-9-2-11-33-22/h3-8,14,20,22,27H,2,9-13,16H2,1H3,(H,28,30)/t20-,22-/m0/s1 | PDB
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TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2H99949 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385058
((2S)-N-[(1S)-1-Cyano-2-{4-[3-(2-methoxyethyl)-2-ox...)Show SMILES COCCn1c2cc(ccc2sc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 Show InChI InChI=1S/C25H28N4O4S/c1-32-12-10-29-21-14-19(7-8-23(21)34-25(29)31)18-5-3-17(4-6-18)13-20(15-26)28-24(30)22-16-27-9-2-11-33-22/h3-8,14,20,22,27H,2,9-13,16H2,1H3,(H,28,30)/t20-,22-/m0/s1 | PDB
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ASTRAZENECA AB
US Patent
| Assay Description
The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic... |
US Patent US10669245 (2020)
BindingDB Entry DOI: 10.7270/Q2862KG7 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50195235
(CHEMBL3900409 | US10287258, Example 2 | US10669245...)Show SMILES Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| Show InChI InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 | PDB
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TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2F76HN2 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50195235
(CHEMBL3900409 | US10287258, Example 2 | US10669245...)Show SMILES Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| Show InChI InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 | PDB
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Novartis
| Assay Description
The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic... |
J Med Chem 51: 7049-52 (2008)
BindingDB Entry DOI: 10.7270/Q2RJ4MTP |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50195235
(CHEMBL3900409 | US10287258, Example 2 | US10669245...)Show SMILES Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| Show InChI InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 | PDB
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TBA
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Citation and Details
BindingDB Entry DOI: 10.7270/Q2FB56W4 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50195235
(CHEMBL3900409 | US10287258, Example 2 | US10669245...)Show SMILES Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| Show InChI InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 | PDB
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TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2ZG6X5T |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50195235
(CHEMBL3900409 | US10287258, Example 2 | US10669245...)Show SMILES Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| Show InChI InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 | PDB
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TBA
| Assay Description
Examples 1-35: The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2Q243DZ |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50195235
(CHEMBL3900409 | US10287258, Example 2 | US10669245...)Show SMILES Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| Show InChI InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 | PDB
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Citation and Details
BindingDB Entry DOI: 10.7270/Q24X5CXQ |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50195235
(CHEMBL3900409 | US10287258, Example 2 | US10669245...)Show SMILES Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| Show InChI InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 | PDB
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Citation and Details
BindingDB Entry DOI: 10.7270/Q2H99949 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50195235
(CHEMBL3900409 | US10287258, Example 2 | US10669245...)Show SMILES Cn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| Show InChI InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1 | PDB
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ASTRAZENECA AB
US Patent
| Assay Description
The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic... |
US Patent US10669245 (2020)
BindingDB Entry DOI: 10.7270/Q2862KG7 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385076
(BDBM445984 | US10287258, Example 36 | US11667615, ...)Show SMILES CC[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 |r| Show InChI InChI=1S/C20H27N3O3/c1-2-16(22-20(25)18-14-21-11-5-13-26-18)8-9-19(24)23-12-10-15-6-3-4-7-17(15)23/h3-4,6-9,16,18,21H,2,5,10-14H2,1H3,(H,22,25)/b9-8+/t16-,18-/m0/s1 | PDB
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Citation and Details
BindingDB Entry DOI: 10.7270/Q2ZG6X5T |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385076
(BDBM445984 | US10287258, Example 36 | US11667615, ...)Show SMILES CC[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 |r| Show InChI InChI=1S/C20H27N3O3/c1-2-16(22-20(25)18-14-21-11-5-13-26-18)8-9-19(24)23-12-10-15-6-3-4-7-17(15)23/h3-4,6-9,16,18,21H,2,5,10-14H2,1H3,(H,22,25)/b9-8+/t16-,18-/m0/s1 | PDB
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Citation and Details
BindingDB Entry DOI: 10.7270/Q24X5CXQ |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385076
(BDBM445984 | US10287258, Example 36 | US11667615, ...)Show SMILES CC[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 |r| Show InChI InChI=1S/C20H27N3O3/c1-2-16(22-20(25)18-14-21-11-5-13-26-18)8-9-19(24)23-12-10-15-6-3-4-7-17(15)23/h3-4,6-9,16,18,21H,2,5,10-14H2,1H3,(H,22,25)/b9-8+/t16-,18-/m0/s1 | PDB
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Citation and Details
BindingDB Entry DOI: 10.7270/Q2F76HN2 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385076
(BDBM445984 | US10287258, Example 36 | US11667615, ...)Show SMILES CC[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 |r| Show InChI InChI=1S/C20H27N3O3/c1-2-16(22-20(25)18-14-21-11-5-13-26-18)8-9-19(24)23-12-10-15-6-3-4-7-17(15)23/h3-4,6-9,16,18,21H,2,5,10-14H2,1H3,(H,22,25)/b9-8+/t16-,18-/m0/s1 | PDB
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Novartis
| Assay Description
The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic... |
J Med Chem 51: 7049-52 (2008)
BindingDB Entry DOI: 10.7270/Q2RJ4MTP |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385076
(BDBM445984 | US10287258, Example 36 | US11667615, ...)Show SMILES CC[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 |r| Show InChI InChI=1S/C20H27N3O3/c1-2-16(22-20(25)18-14-21-11-5-13-26-18)8-9-19(24)23-12-10-15-6-3-4-7-17(15)23/h3-4,6-9,16,18,21H,2,5,10-14H2,1H3,(H,22,25)/b9-8+/t16-,18-/m0/s1 | PDB
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Citation and Details
BindingDB Entry DOI: 10.7270/Q2FB56W4 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385076
(BDBM445984 | US10287258, Example 36 | US11667615, ...)Show SMILES CC[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 |r| Show InChI InChI=1S/C20H27N3O3/c1-2-16(22-20(25)18-14-21-11-5-13-26-18)8-9-19(24)23-12-10-15-6-3-4-7-17(15)23/h3-4,6-9,16,18,21H,2,5,10-14H2,1H3,(H,22,25)/b9-8+/t16-,18-/m0/s1 | PDB
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TBA
| Assay Description
Examples 36-37: The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gl... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2Q243DZ |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385076
(BDBM445984 | US10287258, Example 36 | US11667615, ...)Show SMILES CC[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 |r| Show InChI InChI=1S/C20H27N3O3/c1-2-16(22-20(25)18-14-21-11-5-13-26-18)8-9-19(24)23-12-10-15-6-3-4-7-17(15)23/h3-4,6-9,16,18,21H,2,5,10-14H2,1H3,(H,22,25)/b9-8+/t16-,18-/m0/s1 | PDB
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Citation and Details
BindingDB Entry DOI: 10.7270/Q2H99949 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385076
(BDBM445984 | US10287258, Example 36 | US11667615, ...)Show SMILES CC[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 |r| Show InChI InChI=1S/C20H27N3O3/c1-2-16(22-20(25)18-14-21-11-5-13-26-18)8-9-19(24)23-12-10-15-6-3-4-7-17(15)23/h3-4,6-9,16,18,21H,2,5,10-14H2,1H3,(H,22,25)/b9-8+/t16-,18-/m0/s1 | PDB
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ASTRAZENECA AB
US Patent
| Assay Description
The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic... |
US Patent US10669245 (2020)
BindingDB Entry DOI: 10.7270/Q2862KG7 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385055
((2S)-N-{(1S)-1-Cyano-2-[4-(7-fluoro-3-methyl-2-oxo...)Show SMILES Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 Show InChI InChI=1S/C23H23FN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1 | PDB
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ASTRAZENECA AB
US Patent
| Assay Description
The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic... |
US Patent US10669245 (2020)
BindingDB Entry DOI: 10.7270/Q2862KG7 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385055
((2S)-N-{(1S)-1-Cyano-2-[4-(7-fluoro-3-methyl-2-oxo...)Show SMILES Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 Show InChI InChI=1S/C23H23FN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1 | PDB
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Citation and Details
BindingDB Entry DOI: 10.7270/Q2FB56W4 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385055
((2S)-N-{(1S)-1-Cyano-2-[4-(7-fluoro-3-methyl-2-oxo...)Show SMILES Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 Show InChI InChI=1S/C23H23FN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1 | PDB
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Citation and Details
BindingDB Entry DOI: 10.7270/Q2ZG6X5T |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385055
((2S)-N-{(1S)-1-Cyano-2-[4-(7-fluoro-3-methyl-2-oxo...)Show SMILES Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 Show InChI InChI=1S/C23H23FN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1 | PDB
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Citation and Details
BindingDB Entry DOI: 10.7270/Q2H99949 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385055
((2S)-N-{(1S)-1-Cyano-2-[4-(7-fluoro-3-methyl-2-oxo...)Show SMILES Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 Show InChI InChI=1S/C23H23FN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1 | PDB
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Citation and Details
BindingDB Entry DOI: 10.7270/Q2F76HN2 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385055
((2S)-N-{(1S)-1-Cyano-2-[4-(7-fluoro-3-methyl-2-oxo...)Show SMILES Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 Show InChI InChI=1S/C23H23FN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1 | PDB
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Novartis
| Assay Description
The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic... |
J Med Chem 51: 7049-52 (2008)
BindingDB Entry DOI: 10.7270/Q2RJ4MTP |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385055
((2S)-N-{(1S)-1-Cyano-2-[4-(7-fluoro-3-methyl-2-oxo...)Show SMILES Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 Show InChI InChI=1S/C23H23FN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1 | PDB
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Citation and Details
BindingDB Entry DOI: 10.7270/Q24X5CXQ |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385055
((2S)-N-{(1S)-1-Cyano-2-[4-(7-fluoro-3-methyl-2-oxo...)Show SMILES Cn1c2cc(cc(F)c2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 Show InChI InChI=1S/C23H23FN4O4/c1-28-19-11-16(10-18(24)21(19)32-23(28)30)15-5-3-14(4-6-15)9-17(12-25)27-22(29)20-13-26-7-2-8-31-20/h3-6,10-11,17,20,26H,2,7-9,13H2,1H3,(H,27,29)/t17-,20-/m0/s1 | PDB
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TBA
| Assay Description
Examples 1-35: The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2Q243DZ |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385077
(BDBM445985 | US10287258, Example 37 | US11667615, ...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 |r| Show InChI InChI=1S/C22H31N3O3/c1-16(2)14-18(24-22(27)20-15-23-11-5-13-28-20)8-9-21(26)25-12-10-17-6-3-4-7-19(17)25/h3-4,6-9,16,18,20,23H,5,10-15H2,1-2H3,(H,24,27)/b9-8+/t18-,20+/m1/s1 | PDB
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TBA
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Citation and Details
BindingDB Entry DOI: 10.7270/Q2H99949 |
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Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385077
(BDBM445985 | US10287258, Example 37 | US11667615, ...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 |r| Show InChI InChI=1S/C22H31N3O3/c1-16(2)14-18(24-22(27)20-15-23-11-5-13-28-20)8-9-21(26)25-12-10-17-6-3-4-7-19(17)25/h3-4,6-9,16,18,20,23H,5,10-15H2,1-2H3,(H,24,27)/b9-8+/t18-,20+/m1/s1 | PDB
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TBA
| Assay Description
Examples 36-37: The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gl... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2Q243DZ |
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Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385077
(BDBM445985 | US10287258, Example 37 | US11667615, ...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 |r| Show InChI InChI=1S/C22H31N3O3/c1-16(2)14-18(24-22(27)20-15-23-11-5-13-28-20)8-9-21(26)25-12-10-17-6-3-4-7-19(17)25/h3-4,6-9,16,18,20,23H,5,10-15H2,1-2H3,(H,24,27)/b9-8+/t18-,20+/m1/s1 | PDB
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Citation and Details
BindingDB Entry DOI: 10.7270/Q2ZG6X5T |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385077
(BDBM445985 | US10287258, Example 37 | US11667615, ...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 |r| Show InChI InChI=1S/C22H31N3O3/c1-16(2)14-18(24-22(27)20-15-23-11-5-13-28-20)8-9-21(26)25-12-10-17-6-3-4-7-19(17)25/h3-4,6-9,16,18,20,23H,5,10-15H2,1-2H3,(H,24,27)/b9-8+/t18-,20+/m1/s1 | PDB
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Citation and Details
BindingDB Entry DOI: 10.7270/Q2F76HN2 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385077
(BDBM445985 | US10287258, Example 37 | US11667615, ...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 |r| Show InChI InChI=1S/C22H31N3O3/c1-16(2)14-18(24-22(27)20-15-23-11-5-13-28-20)8-9-21(26)25-12-10-17-6-3-4-7-19(17)25/h3-4,6-9,16,18,20,23H,5,10-15H2,1-2H3,(H,24,27)/b9-8+/t18-,20+/m1/s1 | PDB
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Citation and Details
BindingDB Entry DOI: 10.7270/Q24X5CXQ |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385077
(BDBM445985 | US10287258, Example 37 | US11667615, ...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 |r| Show InChI InChI=1S/C22H31N3O3/c1-16(2)14-18(24-22(27)20-15-23-11-5-13-28-20)8-9-21(26)25-12-10-17-6-3-4-7-19(17)25/h3-4,6-9,16,18,20,23H,5,10-15H2,1-2H3,(H,24,27)/b9-8+/t18-,20+/m1/s1 | PDB
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ASTRAZENECA AB
US Patent
| Assay Description
The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic... |
US Patent US10669245 (2020)
BindingDB Entry DOI: 10.7270/Q2862KG7 |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385077
(BDBM445985 | US10287258, Example 37 | US11667615, ...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 |r| Show InChI InChI=1S/C22H31N3O3/c1-16(2)14-18(24-22(27)20-15-23-11-5-13-28-20)8-9-21(26)25-12-10-17-6-3-4-7-19(17)25/h3-4,6-9,16,18,20,23H,5,10-15H2,1-2H3,(H,24,27)/b9-8+/t18-,20+/m1/s1 | PDB
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Novartis
| Assay Description
The activity of DPP1 was determined by measuring the enzymatic release of aminomethyl coumarin (AMC) from the peptide substrate (H-Gly-Arg-AMC), whic... |
J Med Chem 51: 7049-52 (2008)
BindingDB Entry DOI: 10.7270/Q2RJ4MTP |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM385077
(BDBM445985 | US10287258, Example 37 | US11667615, ...)Show SMILES CC(C)C[C@H](NC(=O)[C@@H]1CNCCCO1)\C=C\C(=O)N1CCc2ccccc12 |r| Show InChI InChI=1S/C22H31N3O3/c1-16(2)14-18(24-22(27)20-15-23-11-5-13-28-20)8-9-21(26)25-12-10-17-6-3-4-7-19(17)25/h3-4,6-9,16,18,20,23H,5,10-15H2,1-2H3,(H,24,27)/b9-8+/t18-,20+/m1/s1 | PDB
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BindingDB Entry DOI: 10.7270/Q2FB56W4 |
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Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM50195246
(CHEMBL3980602 | US10287258, Example 16 | US1066924...)Show SMILES CCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 |r| Show InChI InChI=1S/C24H26N4O4/c1-2-28-20-13-18(8-9-21(20)32-24(28)30)17-6-4-16(5-7-17)12-19(14-25)27-23(29)22-15-26-10-3-11-31-22/h4-9,13,19,22,26H,2-3,10-12,15H2,1H3,(H,27,29)/t19-,22-/m0/s1 | PDB
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TBA
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Citation and Details
BindingDB Entry DOI: 10.7270/Q2ZG6X5T |
More data for this
Ligand-Target Pair | |
Dipeptidyl peptidase 1
(Homo sapiens (Human)) | BDBM604854
((2S)-N-{(1S)-1-Cyano-2-[4-(3-ethyl-7-methyl-2-oxo-...)Show SMILES CCn1c2cc(ccc2oc1=O)-c1ccc(C[C@H](NC(=O)[C@@H]2CNCCCO2)C#N)cc1 | PDB
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TBA
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Citation and Details
BindingDB Entry DOI: 10.7270/Q2H99949 |
More data for this
Ligand-Target Pair | |
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