| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dipeptidyl peptidase 1 |
|---|
| Ligand | BDBM50195263 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Fluorescence assay for recombinant human (RH) DPP1 |
|---|
| IC50 | 61.7±n/a nM |
|---|
| Citation |  Lönn, HR; Connolly, S; Swallow, S; Karlsson, SP; Aurell, C; Pontén, JF; Doyle, KJ; Van De Poël, AJ; Jones, GP; Watson, DW; Macritchie, JA; Palmer, NJ Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors US Patent US11673871 Publication Date 6/13/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dipeptidyl peptidase 1 |
|---|
| Name: | Dipeptidyl peptidase 1 |
|---|
| Synonyms: | CATC_HUMAN | CPPI | CTSC | Cathepsin C | Cathepsin J | Dipeptidyl peptidase 1 (DDPI) | Dipeptidyl peptidase 1 (DPPI) | Dipeptidyl peptidase I | Dipeptidyl peptidase I (DPPI) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 51857.28 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P53634 |
|---|
| Residue: | 463 |
|---|
| Sequence: | MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQ
EKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNE
TMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINA
IQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNV
HGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEG
GFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALM
KLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGM
DYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
|
|
|
|---|
| BDBM50195263 |
|---|
| n/a |
|---|
| Name | BDBM50195263 |
|---|
| Synonyms: | CHEMBL3942969 | US10287258, Example 33 | US10669245, Example 33 | US11117874, Example 33 | US11673871, Example 33 | US11680049, Example 33 | US20230278969, Example 33 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H22N4O2S |
|---|
| Mol. Mass. | 406.501 |
|---|
| SMILES | O=C(N[C@@H](Cc1ccc(cc1)-c1ccc2scnc2c1)C#N)[C@@H]1CNCCCO1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
