Ki Summary

Reaction Details

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Target

GTPase KRas [G12C]

Ligand

BDBM608864

Substrate/Competitor

n/a

Meas. Tech.

Scintillation Proximity Assay (SPA)

IC50

13.0±n/a nM

Citation

Cotesta, S; Gerspacher, M; Leblanc, C; Lorthiois, EL; Liu, B; Machauer, R; Mah, R; Mura, C; Rigollier, P; Schneider, N; Stutz, S; Vaupel, A; Warin, N; Wilcken, R Pyrazolyl derivatives useful as anti-cancer agents US Patent US11702409 Publication Date 7/18/2023

More Info.:

Get all data from this article, Assay Method

GTPase KRas [G12C]

Name:

GTPase KRas [G12C]

Synonyms:

GTPase KRas (G12C) | KRAS | KRAS2 | RASK2 | RASK_HUMAN

Type:

Enzyme Catalytic Domain

Mol. Mass.:

21702.19

Organism:

Homo sapiens (Human)

Description:

P01116[G12C]

Residue:

189

Sequence:

MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM

BDBM608864

n/a

Name

BDBM608864

Synonyms:

US11702409, Example 17a | US11702409, Example 17b

Type

Small organic molecule

Emp. Form.

C34H37ClN8O2

Mol. Mass.

625.163

SMILES

Cc1c(c(nn1C1CC2(C1)CN(C2)C(=O)C=C)-c1ccc2n(CCN3CCOCC3)ncc2c1)-c1c(Cl)c(C)cc2[nH]ncc12 |(-4.14,-.92,;-2.68,-.44,;-1.43,-1.35,;-.19,-.44,;-.66,1.02,;-2.2,1.02,;-2.97,2.35,;-4.46,2.75,;-4.06,4.24,;-2.58,3.84,;-5.55,4.64,;-5.15,6.13,;-3.66,5.73,;-6.24,7.21,;-5.84,8.7,;-7.73,6.82,;-8.82,7.9,;1.28,-.92,;1.6,-2.43,;3.06,-2.9,;4.21,-1.87,;5.74,-2.03,;6.51,-3.37,;5.74,-4.7,;6.51,-6.03,;5.74,-7.37,;6.51,-8.7,;8.05,-8.7,;8.82,-7.37,;8.05,-6.03,;6.36,-.63,;5.22,.4,;3.89,-.37,;2.42,.11,;-1.43,-2.89,;-2.77,-3.66,;-4.1,-2.89,;-2.77,-5.2,;-4.1,-5.97,;-1.43,-5.97,;-.1,-5.2,;1.36,-5.68,;2.27,-4.43,;1.36,-3.18,;-.1,-3.66,)|

Structure