Ki Summary

Reaction Details

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Target

GTPase KRas [G12C]

Ligand

BDBM608928

Substrate/Competitor

n/a

Meas. Tech.

Scintillation Proximity Assay (SPA)

IC50

112±n/a nM

Citation

Cotesta, S; Gerspacher, M; Leblanc, C; Lorthiois, EL; Liu, B; Machauer, R; Mah, R; Mura, C; Rigollier, P; Schneider, N; Stutz, S; Vaupel, A; Warin, N; Wilcken, R Pyrazolyl derivatives useful as anti-cancer agents US Patent US11702409 Publication Date 7/18/2023

More Info.:

Get all data from this article, Assay Method

GTPase KRas [G12C]

Name:

GTPase KRas [G12C]

Synonyms:

GTPase KRas (G12C) | KRAS | KRAS2 | RASK2 | RASK_HUMAN

Type:

Enzyme Catalytic Domain

Mol. Mass.:

21702.19

Organism:

Homo sapiens (Human)

Description:

P01116[G12C]

Residue:

189

Sequence:

MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM

BDBM608928

n/a

Name

BDBM608928

Synonyms:

US11702409, Example 37a | US11702409, Example 37b

Type

Small organic molecule

Emp. Form.

C28H27ClN8O

Mol. Mass.

527.02

SMILES

Cc1c(c(nn1C1CC2(C1)CN(C2)C(=O)C=C)-c1cnc2n(C)ncc2c1)-c1c(Cl)c(C)cc2[nH]ncc12 |(-2.99,-2.29,;-1.52,-1.81,;-.28,-2.72,;.97,-1.81,;.49,-.35,;-1.05,-.35,;-1.82,.99,;-3.31,1.39,;-2.91,2.87,;-1.42,2.48,;-4.4,3.27,;-4,4.76,;-2.51,4.36,;-5.09,5.85,;-4.69,7.34,;-6.57,5.45,;-7.66,6.54,;2.43,-2.29,;2.75,-3.79,;4.22,-4.27,;5.36,-3.24,;6.89,-3.4,;7.66,-4.73,;7.52,-1.99,;6.37,-.96,;5.04,-1.73,;3.58,-1.26,;-.28,-4.26,;-1.61,-5.03,;-2.95,-4.26,;-1.61,-6.57,;-2.95,-7.34,;-.28,-7.34,;1.05,-6.57,;2.52,-7.04,;3.42,-5.8,;2.52,-4.55,;1.05,-5.03,)|

Structure