Reaction Details | |||
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Target | GTPase KRas [G12C] | ||
Ligand | BDBM608939 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Scintillation Proximity Assay (SPA) | ||
IC50 | 12.0±n/a nM | ||
Citation | Cotesta, S; Gerspacher, M; Leblanc, C; Lorthiois, EL; Liu, B; Machauer, R; Mah, R; Mura, C; Rigollier, P; Schneider, N; Stutz, S; Vaupel, A; Warin, N; Wilcken, R Pyrazolyl derivatives useful as anti-cancer agents US Patent US11702409 Publication Date 7/18/2023 | ||
More Info.: | Get all data from this article, Assay Method | ||
GTPase KRas [G12C] | |||
Name: | GTPase KRas [G12C] | ||
Synonyms: | GTPase KRas (G12C) | KRAS | KRAS2 | RASK2 | RASK_HUMAN | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 21702.19 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P01116[G12C] | ||
Residue: | 189 | ||
Sequence: |
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BDBM608939 | |||
n/a | |||
Name | BDBM608939 | ||
Synonyms: | US11702409, Example 42a | US11702409, Example 42b | ||
Type | Small organic molecule | ||
Emp. Form. | C32H34ClN7O2 | ||
Mol. Mass. | 584.111 | ||
SMILES | Cc1c(c(nn1C1CC2(C1)CN(C2)C(=O)C=C)-c1ccc2nn(CC(C)(C)O)cc2c1)-c1c(Cl)c(C)cc2[nH]ncc12 |(-4.95,-2.29,;-3.49,-1.81,;-2.24,-2.72,;-.99,-1.81,;-1.47,-.35,;-3.01,-.35,;-3.78,.99,;-5.27,1.39,;-4.87,2.87,;-3.38,2.48,;-6.36,3.27,;-5.96,4.76,;-4.47,4.36,;-7.05,5.85,;-6.65,7.34,;-8.53,5.45,;-9.62,6.54,;.47,-2.29,;.79,-3.79,;2.26,-4.27,;3.4,-3.24,;4.93,-3.4,;5.56,-1.99,;7.05,-1.59,;8.13,-2.68,;9.62,-2.28,;8.53,-4.17,;7.05,-3.77,;4.41,-.96,;3.08,-1.73,;1.62,-1.26,;-2.24,-4.26,;-3.57,-5.03,;-4.91,-4.26,;-3.57,-6.57,;-4.91,-7.34,;-2.24,-7.34,;-.91,-6.57,;.56,-7.04,;1.46,-5.8,;.56,-4.55,;-.91,-5.03,)| | ||
Structure |