Ki Summary

Reaction Details

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Target

GTPase KRas [G12C]

Ligand

BDBM608943

Substrate/Competitor

n/a

Meas. Tech.

Scintillation Proximity Assay (SPA)

IC50

19.0±n/a nM

Citation

Cotesta, S; Gerspacher, M; Leblanc, C; Lorthiois, EL; Liu, B; Machauer, R; Mah, R; Mura, C; Rigollier, P; Schneider, N; Stutz, S; Vaupel, A; Warin, N; Wilcken, R Pyrazolyl derivatives useful as anti-cancer agents US Patent US11702409 Publication Date 7/18/2023

More Info.:

Get all data from this article, Assay Method

GTPase KRas [G12C]

Name:

GTPase KRas [G12C]

Synonyms:

GTPase KRas (G12C) | KRAS | KRAS2 | RASK2 | RASK_HUMAN

Type:

Enzyme Catalytic Domain

Mol. Mass.:

21702.19

Organism:

Homo sapiens (Human)

Description:

P01116[G12C]

Residue:

189

Sequence:

MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM

BDBM608943

n/a

Name

BDBM608943

Synonyms:

US11702409, Example 44a | US11702409, Example 44b

Type

Small organic molecule

Emp. Form.

C32H35ClN6O2

Mol. Mass.

571.112

SMILES

COCCN1CCc2cc(ccc12)-c1nn(C2CC3(C2)CN(C3)C(=O)C=C)c(C)c1-c1c(Cl)c(C)cc2[nH]ncc12 |(9.59,-6.07,;8.05,-6.07,;7.28,-4.73,;5.74,-4.73,;4.97,-3.4,;5.59,-1.99,;4.45,-.96,;3.12,-1.73,;1.65,-1.26,;.51,-2.29,;.83,-3.79,;2.29,-4.27,;3.44,-3.24,;-.96,-1.81,;-1.43,-.35,;-2.97,-.35,;-3.74,.99,;-5.23,1.39,;-4.83,2.87,;-3.35,2.48,;-6.32,3.27,;-5.92,4.76,;-4.43,4.36,;-7.01,5.85,;-6.61,7.34,;-8.5,5.45,;-9.59,6.54,;-3.45,-1.81,;-4.91,-2.29,;-2.2,-2.72,;-2.2,-4.26,;-3.54,-5.03,;-4.87,-4.26,;-3.54,-6.57,;-4.87,-7.34,;-2.2,-7.34,;-.87,-6.57,;.59,-7.04,;1.5,-5.8,;.59,-4.55,;-.87,-5.03,)|

Structure