Ki Summary

Reaction Details

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Target

GTPase KRas [G12C]

Ligand

BDBM608984

Substrate/Competitor

n/a

Meas. Tech.

Scintillation Proximity Assay (SPA)

IC50

46.0±n/a nM

Citation

Cotesta, S; Gerspacher, M; Leblanc, C; Lorthiois, EL; Liu, B; Machauer, R; Mah, R; Mura, C; Rigollier, P; Schneider, N; Stutz, S; Vaupel, A; Warin, N; Wilcken, R Pyrazolyl derivatives useful as anti-cancer agents US Patent US11702409 Publication Date 7/18/2023

More Info.:

Get all data from this article, Assay Method

GTPase KRas [G12C]

Name:

GTPase KRas [G12C]

Synonyms:

GTPase KRas (G12C) | KRAS | KRAS2 | RASK2 | RASK_HUMAN

Type:

Enzyme Catalytic Domain

Mol. Mass.:

21702.19

Organism:

Homo sapiens (Human)

Description:

P01116[G12C]

Residue:

189

Sequence:

MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
VKIKKCIIM

BDBM608984

n/a

Name

BDBM608984

Synonyms:

US11702409, Example 65a | US11702409, Example 65b

Type

Small organic molecule

Emp. Form.

C32H36ClN7O2

Mol. Mass.

586.127

SMILES

CN(C)CCNC(=O)c1ccc(cc1)-c1nn(C2CC3(C2)CN(C3)C(=O)C=C)c(C)c1-c1c(Cl)c(C)cc2[nH]ncc12 |(9.33,-6.4,;8.93,-4.91,;10.02,-3.82,;7.44,-4.51,;7.04,-3.02,;5.56,-2.63,;4.47,-3.71,;4.79,-5.22,;3,-3.24,;1.86,-4.27,;.39,-3.79,;.07,-2.29,;1.22,-1.26,;2.68,-1.73,;-1.39,-1.81,;-1.87,-.35,;-3.41,-.35,;-4.18,.99,;-5.66,1.39,;-5.27,2.87,;-3.78,2.48,;-6.75,3.27,;-6.35,4.76,;-4.87,4.36,;-7.44,5.85,;-7.04,7.34,;-8.93,5.45,;-10.02,6.54,;-3.88,-1.81,;-5.35,-2.29,;-2.64,-2.72,;-2.64,-4.26,;-3.97,-5.03,;-5.3,-4.26,;-3.97,-6.57,;-5.3,-7.34,;-2.64,-7.34,;-1.3,-6.57,;.16,-7.04,;1.07,-5.8,;.16,-4.55,;-1.3,-5.03,)|

Structure