| Reaction Details |
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 | Report a problem with these data |
| Target | Son of sevenless homolog 1 [564-1049] |
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| Ligand | BDBM609528 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition of Labeled Tracer Ligand |
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| Ki | 0.200±n/a nM |
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| Citation |  Marx, MA; Ketcham, JM; Smith, CR; Lawson, JD; Burns, AC; Wang, X; Kulyk, S; Ivetac, A SOS1 inhibitors US Patent US11702418 Publication Date 7/18/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Son of sevenless homolog 1 [564-1049] |
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| Name: | Son of sevenless homolog 1 [564-1049] |
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| Synonyms: | SOS1 | SOS1_HUMAN | Son of sevenless homolog 1 (SOS1)(564-1049) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 56970.22 |
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| Organism: | n/a |
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| Description: | aa 564-1049 |
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| Residue: | 486 |
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| Sequence: | EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNF
VRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQ
PVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIA
RDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSE
LVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQ
ELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSIN
PPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRV
ESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPS
NPRPGT
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| BDBM609528 |
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| n/a |
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| Name | BDBM609528 |
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| Synonyms: | (R)-4-methyl-7-(4-(1-methyl-1H-pyrazol-4-yl)piperazin-1-yl)-N-(1-(2-methyl-3-(trifluoromethyl)phenyl)ethyl)pyrido[3,4-d]pyridazin-1-amine | US11702418, Example 12-1 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H29F3N8 |
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| Mol. Mass. | 510.5573 |
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| SMILES | C[C@@H](Nc1nnc(C)c2cnc(cc12)N1CCN(CC1)c1cnn(C)c1)c1cccc(c1C)C(F)(F)F |r| |
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| Structure | 
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