| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cGMP-specific 3',5'-cyclic phosphodiesterase |
|---|
| Ligand | BDBM480488 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | PDE5 Inhibition Assay |
|---|
| IC50 | 43.8±n/a nM |
|---|
| Citation |  Landry, DW; Deng, S; Arancio, O; Fiorito, J; Wasmuth, A Phosphodiesterase inhibitors and uses thereof US Patent US10626113 Publication Date 4/21/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cGMP-specific 3',5'-cyclic phosphodiesterase |
|---|
| Name: | cGMP-specific 3',5'-cyclic phosphodiesterase |
|---|
| Synonyms: | 3',5'-cyclic phosphodiesterase | CGB-PDE | PDE5 | PDE5A | PDE5A_HUMAN | Phosphodiesterase 2 and 5 (PDE2 and PDE5) | Phosphodiesterase 5 (PDE5) | Phosphodiesterase 5A | Phosphodiesterase 5A (PDE5A) | cGMP-binding cGMP-specific phosphodiesterase | cGMP-specific 3',5'-cyclic phosphodiesterase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 99975.83 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O76074 |
|---|
| Residue: | 875 |
|---|
| Sequence: | MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAE
RVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEG
TVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLI
SADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPL
NIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDE
KDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIIS
FMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTME
PLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK
VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETREL
QSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWIL
SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV
NNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAI
LATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAE
LVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCF
PLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
|
|
|
|---|
| BDBM480488 |
|---|
| n/a |
|---|
| Name | BDBM480488 |
|---|
| Synonyms: | US10626113, Compound E | US10899756, Compound E |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H18ClN5O2 |
|---|
| Mol. Mass. | 407.853 |
|---|
| SMILES | COc1ccc(CNc2c3c(NCCNC3=O)nc3ccc(cc23)C#N)cc1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
