| Reaction Details |
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 | Report a problem with these data |
| Target | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha |
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| Ligand | BDBM50241831 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PDE5 Inhibition Assay |
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| IC50 | 30.1±n/a nM |
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| Citation |  Landry, DW; Deng, S; Arancio, O; Fiorito, J; Wasmuth, A Phosphodiesterase inhibitors and uses thereof US Patent US10626113 Publication Date 4/21/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha |
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| Name: | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha |
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| Synonyms: | PDE6A | PDE6A_HUMAN | PDEA | Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 99531.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1347866 |
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| Residue: | 860 |
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| Sequence: | MGEVTAEEVEKFLDSNIGFAKQYYNLHYRAKLISDLLGAKEAAVDFSNYHSPSSMEESEI
IFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVHKDAV
LEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILAS
PIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQI
LLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVP
PYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICNIM
NAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLM
ESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPW
ECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQE
ALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD
IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIH
MMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACD
LSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFV
CTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKKQKQQSAKSAAAGN
QPGGNPSPGGATTSKSCCIQ
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| BDBM50241831 |
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| n/a |
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| Name | BDBM50241831 |
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| Synonyms: | CHEMBL4062273 | US10626113, Compound M | US10899756, Compound U |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21ClN4O2 |
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| Mol. Mass. | 420.891 |
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| SMILES | COc1ccc(CNc2c3CN(CCc3nc3ccc(cc23)C#N)C(C)=O)cc1Cl |
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| Structure | 
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