| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PLK1 |
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| Ligand | BDBM50548903 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ELISA-based PBD-binding inhibition assay |
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| IC50 | 870±70 nM |
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| Citation |  Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K PLK1 POLO BOX DOMAIN INHIBITORS AND METHOD OF TREATING CANCER US Patent US20230365568 Publication Date 11/16/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PLK1 |
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| Name: | Serine/threonine-protein kinase PLK1 |
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| Synonyms: | PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 68277.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P53350 |
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| Residue: | 603 |
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| Sequence: | MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG
KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF
EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG
NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI
MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL
NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE
PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK
YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK
LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL
KAS
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| BDBM50548903 |
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| n/a |
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| Name | BDBM50548903 |
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| Synonyms: | CHEMBL4755098 | US20230365568, Compound 83 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H12FN5OS |
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| Mol. Mass. | 341.363 |
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| SMILES | Fc1ccc2c(c1)c(=O)n(CCc1ccccn1)c1n[nH]c(=S)n21 |
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| Structure | 
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