Reaction Details |
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Target | Serine/threonine-protein kinase PLK1 |
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Ligand | BDBM60899 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ELISA-based PBD-binding inhibition assay |
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IC50 | 1030±80 nM |
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Citation | Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K PLK1 POLO BOX DOMAIN INHIBITORS AND METHOD OF TREATING CANCER US Patent US20230365568 Publication Date 11/16/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase PLK1 |
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Name: | Serine/threonine-protein kinase PLK1 |
Synonyms: | PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 68277.16 |
Organism: | Homo sapiens (Human) |
Description: | P53350 |
Residue: | 603 |
Sequence: | MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG
KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF
EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG
NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI
MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL
NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE
PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK
YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK
LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL
KAS
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BDBM60899 |
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n/a |
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Name | BDBM60899 |
Synonyms: | 4-propyl-1-sulfanylidene-2H-[1,2,4]triazolo[4,3-a]quinazolin-5-one | 4-propyl-1-thioxo-2H-[1,2,4]triazolo[4,3-a]quinazolin-5-one | MLS001170914 | SMR000588314 | US20230365568, Compound 21 | cid_2423905 |
Type | Small organic molecule |
Emp. Form. | C12H12N4OS |
Mol. Mass. | 260.315 |
SMILES | CCCn1c2n[nH]c(=S)n2c2ccccc2c1=O |
Structure |
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