| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase 13 |
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| Ligand | BDBM637192 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | LZK Biochemical Assay |
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| IC50 | 29.0±n/a nM |
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| Citation |  Patel, A; Zack, D; Welsbie, D; Berlinicke, C; Lilley, BN; Kim, B; Schirok, H; Schubert, W; Koch, M; Nicolas, L; Terjung, C; Lobell, M; Holton, S; Jungmann, N SUBSTITUTED 4-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)THIOPHENE-2-CARBOXAMIDE DERIVATIVES AND USE THEREOF US Patent US20230382904 Publication Date 11/30/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase kinase kinase 13 |
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| Name: | Mitogen-activated protein kinase kinase kinase 13 |
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| Synonyms: | LZK | Leucine zipper-bearing kinase | M3K13_HUMAN | MAP3K13 | MLK | Mixed lineage kinase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 108293.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774445 |
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| Residue: | 966 |
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| Sequence: | MANFQEHLSCSSSPHLPFSESKTFNGLQDELTAMGNHPSPKLLEDQQEKGMVRTELIESV
HSPVTTTVLTSVSEDSRDQFENSVLQLREHDESETAVSQGNSNTVDGESTSGTEDIKIQF
SRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQG
AVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQ
LYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGT
SKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSA
IIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQE
TYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERAN
NLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPH
KSGMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHS
DFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHG
QDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGP
WGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENAQSSEKTEENE
FSGCRSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCIS
SCQSYSTFSSENFSVSDGEEGNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDIS
SHSDGLSDKECAVRRVKTQMSLGKLCVEERGYENPMQFEESDCDSSDGECSDATVRTNKH
YSSATW
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| BDBM637192 |
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| n/a |
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| Name | BDBM637192 |
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| Synonyms: | 2-Amino-N-[(2S)-butan-2-yl]-6-(5-{[(1S)-1-(4-fluorophenyl)propyl]carbamoyl}thiophen-3-yl)[1,2,4]triazolo[1,5-a]pyridine-8-carboxamide | US20230382904, Compound 112 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27FN6O2S |
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| Mol. Mass. | 494.584 |
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| SMILES | CC[C@H](C)NC(=O)c1cc(cn2nc(N)nc12)-c1csc(c1)C(=O)N[C@@H](CC)c1ccc(F)cc1 |r| |
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| Structure | 
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