| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Receptor tyrosine-protein kinase erbB-2 [676-775,'YVMA',776-1255] |
|---|
| Ligand | BDBM638349 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biochemical Assay |
|---|
| IC50 | 47.6±n/a nM |
|---|
| Citation |  Boys, ML; Ellis, BD; Gaudino, JJ; Hicken, EJ; Laird, ER; Lazzara, NC; Newhouse, BJ; Pajk, SP Substituted pyrimido[5,4-d]pyrimidines as HER2 inhibitors US Patent US11834453 Publication Date 12/5/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Receptor tyrosine-protein kinase erbB-2 [676-775,'YVMA',776-1255] |
|---|
| Name: | Receptor tyrosine-protein kinase erbB-2 [676-775,'YVMA',776-1255] |
|---|
| Synonyms: | ErbB2 insYVMA |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 64508.66 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P04626[676-775,'YVMA',776-1255] |
|---|
| Residue: | 584 |
|---|
| Sequence: | KRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVY
KGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAYVMAGVGSPYVSRLLGICLT
STVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNV
LVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVT
VWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRE
LVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFF
CPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLG
MGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPS
PREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPP
AFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV
|
|
|
|---|
| BDBM638349 |
|---|
| n/a |
|---|
| Name | BDBM638349 |
|---|
| Synonyms: | US11834453, Example 452 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H23ClN8O2 |
|---|
| Mol. Mass. | 502.956 |
|---|
| SMILES | C[C@@H]1CN(CCO1)c1ncc2ncnc(Nc3ccc(Oc4ccc5n(C)cnc5c4)c(Cl)c3)c2n1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
