Compile Data Set for Download or QSAR

Found 4262 hits with Last Name = 'hicken' and Initial = 'ej'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GTPase KRas (Homo sapiens (Human))	BDBM50539763 (Adagrasib | Mrtx-849 | Mrtx849) Show SMILES CN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)C(F)=C)c1cccc2cccc(Cl)c12 Show InChI InChI=1S/C32H35ClFN7O2/c1-21(34)31(42)41-17-16-40(18-23(41)11-13-35)30-25-12-15-39(28-10-4-7-22-6-3-9-26(33)29(22)28)19-27(25)36-32(37-30)43-20-24-8-5-14-38(24)2/h3-4,6-7,9-10,23-24H,1,5,8,11-12,14-20H2,2H3/t23-,24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc Curated by ChEMBL					Assay Description Inhibition of recombinant KRAS G12C mutant (unknown origin) assessed as rate of inactivation by LC-MS analysis				J Med Chem 63: 6679-6693 (2020) Article DOI: 10.1021/acs.jmedchem.9b02052 BindingDB Entry DOI: 10.7270/Q2G164C5
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104202 (US8575145, 79) Show SMILES FC1(COc2cccc3ccc(nc23)-c2nnc3ccc(cn23)C2CC2)CCNCC1 Show InChI InChI=1S/C24H24FN5O/c25-24(10-12-26-13-11-24)15-31-20-3-1-2-17-6-8-19(27-22(17)20)23-29-28-21-9-7-18(14-30(21)23)16-4-5-16/h1-3,6-9,14,16,26H,4-5,10-13,15H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human))	BDBM565148 (US11414404, Ex. # 25 | US11634409, Example 25) Show SMILES Cc1c(Nc2c(F)ccc(NS(=O)(=O)c3cc(F)ccc3F)c2Cl)ccc2ncn(C)c(=O)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.340	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2FT8R02
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human))	BDBM565148 (US11414404, Ex. # 25 | US11634409, Example 25) Show SMILES Cc1c(Nc2c(F)ccc(NS(=O)(=O)c3cc(F)ccc3F)c2Cl)ccc2ncn(C)c(=O)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.340	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged “tracer” bound to B-Raf via TR-FRET from...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JD511G
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104213 (US8575145, 120 | US8575145, 121 | US8575145, 150 |...) Show SMILES FC1CCNCCC1Oc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12 Show InChI InChI=1S/C21H19F2N5O/c22-14-11-13-4-5-16(21-27-26-19-3-1-2-10-28(19)21)25-20(13)18(12-14)29-17-7-9-24-8-6-15(17)23/h1-5,10-12,15,17,24H,6-9H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM193676 (US9670208, Example 295 4-(3-(cyclopropylmethyl)-[1...) Show SMILES Cn1nccc1Nc1cc(ccn1)-c1ccn2c(CC3CC3)nnc2c1 Show InChI InChI=1S/C19H19N7/c1-25-17(5-8-21-25)22-16-11-14(4-7-20-16)15-6-9-26-18(10-13-2-3-13)23-24-19(26)12-15/h4-9,11-13H,2-3,10H2,1H3,(H,20,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9670208 (2017) BindingDB Entry DOI: 10.7270/Q2RJ4GMB
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104204 (US8575145, 81) Show SMILES FC1(COc2cccc3ccc(nc23)-c2nnc3ccc(cn23)-c2ccccc2)CCNCC1 Show InChI InChI=1S/C27H24FN5O/c28-27(13-15-29-16-14-27)18-34-23-8-4-7-20-9-11-22(30-25(20)23)26-32-31-24-12-10-21(17-33(24)26)19-5-2-1-3-6-19/h1-12,17,29H,13-16,18H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.450	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human))	BDBM565192 (US11414404, Ex. # 69 | US11634409, Example 69) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(Oc2ccc3ncn(C)c(=O)c3c2C)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.460	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2FT8R02
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human))	BDBM565192 (US11414404, Ex. # 69 | US11634409, Example 69) Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(Oc2ccc3ncn(C)c(=O)c3c2C)c1C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.460	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged “tracer” bound to B-Raf via TR-FRET from...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JD511G
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104229 (US8575145, 106) Show SMILES Fc1cc(OCC2(F)CCNCC2)c2nc(ccc2c1)-c1nnc2ccccn12 Show InChI InChI=1S/C21H19F2N5O/c22-15-11-14-4-5-16(20-27-26-18-3-1-2-10-28(18)20)25-19(14)17(12-15)29-13-21(23)6-8-24-9-7-21/h1-5,10-12,24H,6-9,13H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM193385 (US9670208, Example 57) Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(Cc3cccc(Cl)c3Cl)nnc2c1 Show InChI InChI=1S/C21H16Cl2N8/c1-30-17(6-9-25-30)27-21-24-8-5-16(26-21)13-7-10-31-18(11-13)28-29-19(31)12-14-3-2-4-15(22)20(14)23/h2-11H,12H2,1H3,(H,24,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9670208 (2017) BindingDB Entry DOI: 10.7270/Q2RJ4GMB
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM41535 (US8575145, 106 | US8575145, 66) Show SMILES FC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCNCC1 Show InChI InChI=1S/C21H26N6O5/c1-5-31-18-8-7-15(9-19(18)32-6-2)12-25-13-16(10-22-25)24-20(28)21(3,4)26-14-17(11-23-26)27(29)30/h7-11,13-14H,5-6,12H2,1-4H3,(H,24,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104162 (US8575145, 39) Show SMILES CC(C)(CN)COc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12 Show InChI InChI=1S/C20H20FN5O/c1-20(2,11-22)12-27-16-10-14(21)9-13-6-7-15(23-18(13)16)19-25-24-17-5-3-4-8-26(17)19/h3-10H,11-12,22H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.550	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM193773 (US9670208, Example 402 4-(3-(4-fluorobenzyl)-[1,2,...) Show SMILES Fc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(NC3CCOCC3)n2)cc1 Show InChI InChI=1S/C22H21FN6O/c23-17-3-1-15(2-4-17)13-20-27-28-21-14-16(6-10-29(20)21)19-5-9-24-22(26-19)25-18-7-11-30-12-8-18/h1-6,9-10,14,18H,7-8,11-13H2,(H,24,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9670208 (2017) BindingDB Entry DOI: 10.7270/Q2RJ4GMB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM193675 (US9670208, Example 279 N-(1-methyl-1H-pyrazol-5-yl...) Show SMILES Cn1nccc1Nc1cc(ccn1)-c1ccn2c(CC(C)(C)C)nnc2c1 Show InChI InChI=1S/C20H23N7/c1-20(2,3)13-19-25-24-18-12-15(7-10-27(18)19)14-5-8-21-16(11-14)23-17-6-9-22-26(17)4/h5-12H,13H2,1-4H3,(H,21,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9670208 (2017) BindingDB Entry DOI: 10.7270/Q2RJ4GMB
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104187 (US8575145, 64) Show SMILES CC(C)(CN)COc1cccc2ccc(nc12)-c1nnc2ccc(cn12)C1CC1 Show InChI InChI=1S/C23H25N5O/c1-23(2,13-24)14-29-19-5-3-4-16-8-10-18(25-21(16)19)22-27-26-20-11-9-17(12-28(20)22)15-6-7-15/h3-5,8-12,15H,6-7,13-14,24H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.640	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104140 (US8575145, 17) Show SMILES NC1CCC(CC1)Oc1cccc2ccc(nc12)-c1nnc2ccccn12 |(7.59,3.85,;6.26,3.08,;6.26,1.54,;4.93,.77,;3.6,1.54,;3.6,3.08,;4.93,3.85,;2.27,.77,;2.27,-.77,;3.61,-1.54,;3.61,-3.08,;2.27,-3.85,;.94,-3.08,;-.4,-3.85,;-1.73,-3.08,;-1.73,-1.54,;-.4,-.77,;.94,-1.54,;-3.06,-.77,;-3.06,.77,;-4.53,1.25,;-5.43,0,;-6.96,-.16,;-7.59,-1.56,;-6.69,-2.81,;-5.15,-2.65,;-4.53,-1.24,)| Show InChI InChI=1S/C21H21N5O/c22-15-8-10-16(11-9-15)27-18-5-3-4-14-7-12-17(23-20(14)18)21-25-24-19-6-1-2-13-26(19)21/h1-7,12-13,15-16H,8-11,22H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.650	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104186 (US8575145, 63) Show SMILES CC(C)(CN)COc1cccc2ccc(nc12)-c1nnc2ccc(Br)cn12 Show InChI InChI=1S/C20H20BrN5O/c1-20(2,11-22)12-27-16-5-3-4-13-6-8-15(23-18(13)16)19-25-24-17-9-7-14(21)10-26(17)19/h3-10H,11-12,22H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.650	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104169 (US8575145, 46/47/48/49/50 | US8575145, 77 | US8575...) Show SMILES FC1CCNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccccn12 Show InChI InChI=1S/C21H20FN5O/c22-15-9-11-23-12-10-17(15)28-18-5-3-4-14-7-8-16(24-20(14)18)21-26-25-19-6-1-2-13-27(19)21/h1-8,13,15,17,23H,9-12H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104237 (US8575145, 114) Show SMILES COC1(COc2cc(F)cc3ccc(nc23)-c2nnc3ccccn23)CCCNCC1 Show InChI InChI=1S/C23H24FN5O2/c1-30-23(8-4-10-25-11-9-23)15-31-19-14-17(24)13-16-6-7-18(26-21(16)19)22-28-27-20-5-2-3-12-29(20)22/h2-3,5-7,12-14,25H,4,8-11,15H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human))	BDBM565143 (US11414404, Ex. # 20 | US11634409, Example 20) Show SMILES Cc1c(Nc2c(F)ccc(NS(=O)(=O)c3ccco3)c2Cl)ccc2ncn(C)c(=O)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2FT8R02
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human))	BDBM565143 (US11414404, Ex. # 20 | US11634409, Example 20) Show SMILES Cc1c(Nc2c(F)ccc(NS(=O)(=O)c3ccco3)c2Cl)ccc2ncn(C)c(=O)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged “tracer” bound to B-Raf via TR-FRET from...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JD511G
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104221 (US8575145, 98) Show SMILES FC1CCNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccc(cn12)C1CC1 Show InChI InChI=1S/C24H24FN5O/c25-18-10-12-26-13-11-20(18)31-21-3-1-2-16-6-8-19(27-23(16)21)24-29-28-22-9-7-17(14-30(22)24)15-4-5-15/h1-3,6-9,14-15,18,20,26H,4-5,10-13H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104142 (US8575145, 19) Show SMILES CC(C)(CO)COc1cccc2ccc(nc12)-c1nnc2cc(CN)ccn12 Show InChI InChI=1S/C21H23N5O2/c1-21(2,12-27)13-28-17-5-3-4-15-6-7-16(23-19(15)17)20-25-24-18-10-14(11-22)8-9-26(18)20/h3-10,27H,11-13,22H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104193 (US8575145, 70) Show SMILES CC(C)C1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCNCC1 Show InChI InChI=1S/C24H27N5O/c1-17(2)24(11-13-25-14-12-24)16-30-20-7-5-6-18-9-10-19(26-22(18)20)23-28-27-21-8-3-4-15-29(21)23/h3-10,15,17,25H,11-14,16H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.75	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104165 (US8575145, 42) Show SMILES N[C@H]1CCC(CC1)Oc1cccc2ccc(nc12)-c1nnc2ccccn12 |r,wU:1.0,(7.59,3.85,;6.26,3.08,;6.26,1.54,;4.93,.77,;3.6,1.54,;3.6,3.08,;4.93,3.85,;2.27,.77,;2.27,-.77,;3.61,-1.54,;3.61,-3.08,;2.27,-3.85,;.94,-3.08,;-.4,-3.85,;-1.73,-3.08,;-1.73,-1.54,;-.4,-.77,;.94,-1.54,;-3.06,-.77,;-3.06,.77,;-4.53,1.25,;-5.43,0,;-6.96,-.16,;-7.59,-1.56,;-6.69,-2.81,;-5.15,-2.65,;-4.53,-1.24,)| Show InChI InChI=1S/C21H21N5O/c22-15-8-10-16(11-9-15)27-18-5-3-4-14-7-12-17(23-20(14)18)21-25-24-19-6-1-2-13-26(19)21/h1-7,12-13,15-16H,8-11,22H2/t15-,16?	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.75	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM193781 (US9670208, Example 493 4-(3-((6-ethoxypyridin-3-yl...) Show SMILES CCOc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(Nc3ccnn3C)n2)cn1 Show InChI InChI=1S/C22H21N9O/c1-3-32-21-5-4-15(14-24-21)12-19-28-29-20-13-16(8-11-31(19)20)17-6-9-23-22(26-17)27-18-7-10-25-30(18)2/h4-11,13-14H,3,12H2,1-2H3,(H,23,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9670208 (2017) BindingDB Entry DOI: 10.7270/Q2RJ4GMB
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM41535 (US8575145, 106 | US8575145, 66) Show SMILES FC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCNCC1 Show InChI InChI=1S/C21H26N6O5/c1-5-31-18-8-7-15(9-19(18)32-6-2)12-25-13-16(10-22-25)24-20(28)21(3,4)26-14-17(11-23-26)27(29)30/h7-11,13-14H,5-6,12H2,1-4H3,(H,24,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104188 (US8575145, 65) Show SMILES CC(C)(CN)COc1cccc2ccc(nc12)-c1nnc2ccc(cn12)-c1ccccc1 Show InChI InChI=1S/C26H25N5O/c1-26(2,16-27)17-32-22-10-6-9-19-11-13-21(28-24(19)22)25-30-29-23-14-12-20(15-31(23)25)18-7-4-3-5-8-18/h3-15H,16-17,27H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM193381 (US9670208, Example 49) Show SMILES COc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(Nc3ccnn3C)n2)cc1 Show InChI InChI=1S/C22H20N8O/c1-29-19(8-11-24-29)26-22-23-10-7-18(25-22)16-9-12-30-20(27-28-21(30)14-16)13-15-3-5-17(31-2)6-4-15/h3-12,14H,13H2,1-2H3,(H,23,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9670208 (2017) BindingDB Entry DOI: 10.7270/Q2RJ4GMB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM191370 (US9670208, Example 35) Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(Cc3cc(ccn3)C3CC3)nnc2c1 Show InChI InChI=1S/C23H21N9/c1-31-20(6-10-26-31)28-23-25-9-5-19(27-23)17-7-11-32-21(13-17)29-30-22(32)14-18-12-16(4-8-24-18)15-2-3-15/h4-13,15H,2-3,14H2,1H3,(H,25,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9670208 (2017) BindingDB Entry DOI: 10.7270/Q2RJ4GMB
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104147 (US8575145, 24) Show SMILES CC(C)(CO)COc1cccc2ccc(nc12)-c1nnc2ccccn12 Show InChI InChI=1S/C20H20N4O2/c1-20(2,12-25)13-26-16-7-5-6-14-9-10-15(21-18(14)16)19-23-22-17-8-3-4-11-24(17)19/h3-11,25H,12-13H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM193672 (US9670208, Example 278 4-(3-(pyridin-2-ylmethyl)-[...) Show SMILES C(c1nnc2cc(ccn12)-c1ccnc(NC2CCOCC2)n1)c1ccccn1 Show InChI InChI=1S/C21H21N7O/c1-2-8-22-17(3-1)14-20-27-26-19-13-15(5-10-28(19)20)18-4-9-23-21(25-18)24-16-6-11-29-12-7-16/h1-5,8-10,13,16H,6-7,11-12,14H2,(H,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9670208 (2017) BindingDB Entry DOI: 10.7270/Q2RJ4GMB
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104213 (US8575145, 120 | US8575145, 121 | US8575145, 150 |...) Show SMILES FC1CCNCCC1Oc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12 Show InChI InChI=1S/C21H19F2N5O/c22-14-11-13-4-5-16(21-27-26-19-3-1-2-10-28(19)21)25-20(13)18(12-14)29-17-7-9-24-8-6-15(17)23/h1-5,10-12,15,17,24H,6-9H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM193396 (US9670208, Example 121) Show SMILES Cn1nccc1Nc1cc(ccn1)-c1ccn2c(nnc2c1)[C@H](O)Cc1ccccc1 |r| Show InChI InChI=1S/C23H21N7O/c1-29-21(8-11-25-29)26-20-14-17(7-10-24-20)18-9-12-30-22(15-18)27-28-23(30)19(31)13-16-5-3-2-4-6-16/h2-12,14-15,19,31H,13H2,1H3,(H,24,26)/t19-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9670208 (2017) BindingDB Entry DOI: 10.7270/Q2RJ4GMB
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104246 (US8575145, 123) Show SMILES Cc1ccn2c(nnc2c1)-c1ccc2cccc(OCC(C)(C)CN)c2n1 Show InChI InChI=1S/C21H23N5O/c1-14-9-10-26-18(11-14)24-25-20(26)16-8-7-15-5-4-6-17(19(15)23-16)27-13-21(2,3)12-22/h4-11H,12-13,22H2,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM193776 (US9670208, Example 403 4-(3-(3-fluoro-4-methoxyben...) Show SMILES COc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(NC3CCOCC3)n2)cc1F Show InChI InChI=1S/C23H23FN6O2/c1-31-20-3-2-15(12-18(20)24)13-21-28-29-22-14-16(5-9-30(21)22)19-4-8-25-23(27-19)26-17-6-10-32-11-7-17/h2-5,8-9,12,14,17H,6-7,10-11,13H2,1H3,(H,25,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9670208 (2017) BindingDB Entry DOI: 10.7270/Q2RJ4GMB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM193410 (US9670208, Example 272 4-(3-((6-methoxypyridin-3-y...) Show SMILES COc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(NC3CCOCC3)n2)cn1 Show InChI InChI=1S/C22H23N7O2/c1-30-21-3-2-15(14-24-21)12-19-27-28-20-13-16(5-9-29(19)20)18-4-8-23-22(26-18)25-17-6-10-31-11-7-17/h2-5,8-9,13-14,17H,6-7,10-12H2,1H3,(H,23,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9670208 (2017) BindingDB Entry DOI: 10.7270/Q2RJ4GMB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM193412 (US9670208, Example 276 N-(1-methyl-1H-pyrazol-5-yl...) Show SMILES Cc1ccnc(Cc2nnc3cc(ccn23)-c2ccnc(Nc3ccnn3C)n2)c1 Show InChI InChI=1S/C21H19N9/c1-14-3-7-22-16(11-14)13-20-28-27-19-12-15(6-10-30(19)20)17-4-8-23-21(25-17)26-18-5-9-24-29(18)2/h3-12H,13H2,1-2H3,(H,23,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9670208 (2017) BindingDB Entry DOI: 10.7270/Q2RJ4GMB
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Rattus norvegicus (Rat))	BDBM104213 (US8575145, 120 | US8575145, 121 | US8575145, 150 |...) Show SMILES FC1CCNCCC1Oc1cc(F)cc2ccc(nc12)-c1nnc2ccccn12 Show InChI InChI=1S/C21H19F2N5O/c22-14-11-13-4-5-16(21-27-26-19-3-1-2-10-28(19)21)25-20(13)18(12-14)29-17-7-9-24-8-6-15(17)23/h1-5,10-12,15,17,24H,6-9H2	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 [8-360] (Homo sapiens (Human))	BDBM193756 (US9670208, Example 317 4-(3-((4,4-difluorocyclohex...) Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(CC3CCC(F)(F)CC3)nnc2c1 Show InChI InChI=1S/C21H22F2N8/c1-30-17(5-10-25-30)27-20-24-9-4-16(26-20)15-6-11-31-18(28-29-19(31)13-15)12-14-2-7-21(22,23)8-3-14/h4-6,9-11,13-14H,2-3,7-8,12H2,1H3,(H,24,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9670208 (2017) BindingDB Entry DOI: 10.7270/Q2RJ4GMB
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104169 (US8575145, 46/47/48/49/50 | US8575145, 77 | US8575...) Show SMILES FC1CCNCCC1Oc1cccc2ccc(nc12)-c1nnc2ccccn12 Show InChI InChI=1S/C21H20FN5O/c22-15-9-11-23-12-10-17(15)28-18-5-3-4-14-7-8-16(24-20(14)18)21-26-25-19-6-1-2-13-27(19)21/h1-8,13,15,17,23H,9-12H2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.920	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104190 (US8575145, 67) Show SMILES CC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCNCC1 Show InChI InChI=1S/C22H23N5O/c1-22(10-12-23-13-11-22)15-28-18-6-4-5-16-8-9-17(24-20(16)18)21-26-25-19-7-2-3-14-27(19)21/h2-9,14,23H,10-13,15H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.950	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104196 (US8575145, 73) Show SMILES COC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCNCC1 Show InChI InChI=1S/C22H23N5O2/c1-28-22(10-12-23-13-11-22)15-29-18-6-4-5-16-8-9-17(24-20(16)18)21-26-25-19-7-2-3-14-27(19)21/h2-9,14,23H,10-13,15H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.960	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104248 (US8575145, 125) Show SMILES COC1(COc2cccc3ccc(nc23)-c2nnc3cc(C)ccn23)CCNCC1 Show InChI InChI=1S/C23H25N5O2/c1-16-8-13-28-20(14-16)26-27-22(28)18-7-6-17-4-3-5-19(21(17)25-18)30-15-23(29-2)9-11-24-12-10-23/h3-8,13-14,24H,9-12,15H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104255 (US8575145, 132) Show SMILES CC(C)(CCN)COc1cccc2ccc(nc12)-c1nnc2ccccn12 Show InChI InChI=1S/C21H23N5O/c1-21(2,11-12-22)14-27-17-7-5-6-15-9-10-16(23-19(15)17)20-25-24-18-8-3-4-13-26(18)20/h3-10,13H,11-12,14,22H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair
GTPase KRas (Homo sapiens (Human))	BDBM50539762 (CHEMBL4632935) Show SMILES CN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)C=C)c1cccc2cccc(C)c12 |r| Show InChI InChI=1S/C33H39N7O2/c1-4-30(41)40-19-18-39(20-25(40)13-15-34)32-27-14-17-38(29-12-6-10-24-9-5-8-23(2)31(24)29)21-28(27)35-33(36-32)42-22-26-11-7-16-37(26)3/h4-6,8-10,12,25-26H,1,7,11,13-14,16-22H2,2-3H3/t25-,26-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc Curated by ChEMBL					Assay Description Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western method				J Med Chem 63: 6679-6693 (2020) Article DOI: 10.1021/acs.jmedchem.9b02052 BindingDB Entry DOI: 10.7270/Q2G164C5
					More data for this Ligand-Target Pair
GTPase KRas (Homo sapiens (Human))	BDBM50539761 (CHEMBL4648852) Show SMILES CN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)C=C)c1cccc2cccc(Cl)c12 |r| Show InChI InChI=1S/C32H36ClN7O2/c1-3-29(41)40-18-17-39(19-23(40)12-14-34)31-25-13-16-38(28-11-5-8-22-7-4-10-26(33)30(22)28)20-27(25)35-32(36-31)42-21-24-9-6-15-37(24)2/h3-5,7-8,10-11,23-24H,1,6,9,12-13,15-21H2,2H3/t23-,24-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc Curated by ChEMBL					Assay Description Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western method				J Med Chem 63: 6679-6693 (2020) Article DOI: 10.1021/acs.jmedchem.9b02052 BindingDB Entry DOI: 10.7270/Q2G164C5
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Mus musculus (mouse))	BDBM50446312 (CHEMBL3109350) Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(OCC3CCNC3)c2n1 Show InChI InChI=1S/C24H26N4O3/c1-29-11-12-30-19-8-10-28-21(15-26-23(28)13-19)20-6-5-18-3-2-4-22(24(18)27-20)31-16-17-7-9-25-14-17/h2-6,8,10,13,15,17,25H,7,9,11-12,14,16H2,1H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Curated by ChEMBL					Assay Description Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...				ACS Med Chem Lett 5: 78-83 (2014) Article DOI: 10.1021/ml4003953 BindingDB Entry DOI: 10.7270/Q23N24VQ
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM104240 (US8575145, 117) Show SMILES COC1(COc2cccc3ccc(nc23)-c2nnc3ccccn23)CCCNCC1 Show InChI InChI=1S/C23H25N5O2/c1-29-23(11-5-13-24-14-12-23)16-30-19-7-4-6-17-9-10-18(25-21(17)19)22-27-26-20-8-2-3-15-28(20)22/h2-4,6-10,15,24H,5,11-14,16H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.4	22
Array BioPharma Inc. US Patent					Assay Description The assay for the determination of PIM activity is based on the incorporation of [33P] ATP into PIM2tide substrate and capture of the radiolabeled pe...				US Patent US8575145 (2013) BindingDB Entry DOI: 10.7270/Q2M90797
					More data for this Ligand-Target Pair

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