| Reaction Details |
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 | Report a problem with these data |
| Target | Membrane primary amine oxidase |
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| Ligand | BDBM309487 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibitory Assay |
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| IC50 | 1.40±n/a nM |
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| Citation |  Matsukawa, T; Masuzaki, K; Kawasaki, A; Akasaka, A; Kawai, Y Benzene or thiophene derivative and use thereof as VAP-1 inhibitor US Patent US9603833 Publication Date 3/28/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Membrane primary amine oxidase |
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| Name: | Membrane primary amine oxidase |
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| Synonyms: | AOC3_RAT | Amine oxidase, copper containing | Aoc3 | Semicarbazide-sensitive amine oxidase/ Vascular adhesion protein 1 (SSAO/VAP-1) | Vascular adhesion protein 1 (VAP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 84979.78 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | O08590 |
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| Residue: | 763 |
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| Sequence: | MTQKTTLVLLALAVITIFALVCVLLAGRSGDGGRLSQPLHCPSVLPSVQPQTHPGQSQPF
ADLSPEELTAVMSFLIKHLGPGLVDAAQARPSDNCVFSVELQLPAKAAALAHLDRGGPPP
VREALAIIFFGGQPKPNVSELVVGPLPHPSYMRDVTVERHGGPLPYYRRPVLTREYQDIQ
EMIFHRELPQASGLLHHCCFYKRQGHNLLKMTTAPRGLQSGDRATWFGIYYNLSGAGFYP
HPIGLELLVDHKALDPALWTIQKVFYQGRYYESLTQLEDMFEAGLVNVVLVPDNGTGGSW
SLKSSVPPGRAPPLQFHPEGPRFSVQGSQVRSSLWAFSFGLGAFSGPRIFDIRFQGERVA
YEISVQEAIALYGGNSPASMSTCYMDGSFGIGKYSTPLTRGVDCPYLATYVDWHFLLESQ
TPKTLRDAFCVFEQNQGLPLRRHHSDFYSHYFGGVVETVLVVRSVATLLNYDYVWDMVFH
SNGAIEVKFHATGYITSAFFFGAGEKFGNRVAEHTLGTVHTHNAHFKVDLDVAGLKNWAW
AEDLAFVPMNVPWQPEFQMQRLQVTRKLLETEEEAAFPLGNATPRYLYLASNHSNKWGHR
RGYRIQILSFAGKPLPQESPIEKAFTWGRYHLAVTQRKEEEPSSSSIYNQNDPWTPTVDF
TDFISNETIAGEDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSP
DSIYFRKDQDVTDCEVNSLACLSQTANCVPDLPAFSHGGFTYK
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| BDBM309487 |
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| n/a |
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| Name | BDBM309487 |
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| Synonyms: | US9603833, Example 109 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H28N6O2 |
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| Mol. Mass. | 396.486 |
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| SMILES | CC(=O)N1CCN(CC1)c1ccc(CCc2ccc(CNC(=O)NN)cc2)nc1 |
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| Structure | 
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