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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Receptor-interacting serine/threonine-protein kinase 1 | ||
| Ligand | BDBM647662 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | RIPK1-ADP-Glo Enzymatic Assay | ||
| EC50 | 696±n/a nM | ||
| Citation |  Chen, JL; Chen, Y; DiMauro, EF; Liu, M; Methot, JL; Musacchio, AJ; Palani, A; Pio, B; Duque, LR; Siliphaivanh, P; Vara, BA RIPK1 INHIBITORS AND METHODS OF USE US Patent US20240025912 Publication Date 1/25/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Receptor-interacting serine/threonine-protein kinase 1 | |||
| Name: | Receptor-interacting serine/threonine-protein kinase 1 | ||
| Synonyms: | Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 75926.99 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13546 | ||
| Residue: | 671 | ||
| Sequence: |
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| BDBM647662 | |||
| n/a | |||
| Name | BDBM647662 | ||
| Synonyms: | (S)-2-(bicyclo[2.1.1]hexan-1-yl)-5- (pyrazin-2-yl)-2,5,6,7-tetrahydro-3H- pyrrolo[2,1-c][1,2,4]triazol-3-one | US20240025912, Compound 1-61 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C15H17N5O | ||
| Mol. Mass. | 283.3284 | ||
| SMILES | O=c1n2[C@@H](CCc2nn1C12CC(C1)CC2)c1cnccn1 |r,wU:3.18,(.66,.94,;.34,-.57,;-1.06,-1.19,;-2.57,-.87,;-3.34,-2.2,;-2.31,-3.35,;-.9,-2.72,;.6,-3.04,;1.37,-1.71,;2.9,-1.55,;3.64,-.19,;5.15,-.47,;4.44,-1.55,;5.36,-2,;3.97,-2.66,;-3.2,.54,;-4.73,.7,;-5.36,2.1,;-4.45,3.35,;-2.92,3.19,;-2.29,1.78,)| | ||
| Structure | 
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