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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Receptor-interacting serine/threonine-protein kinase 1 | ||
| Ligand | BDBM647667 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | RIPK1-ADP-Glo Enzymatic Assay | ||
| EC50 | 31.1±n/a nM | ||
| Citation |  Chen, JL; Chen, Y; DiMauro, EF; Liu, M; Methot, JL; Musacchio, AJ; Palani, A; Pio, B; Duque, LR; Siliphaivanh, P; Vara, BA RIPK1 INHIBITORS AND METHODS OF USE US Patent US20240025912 Publication Date 1/25/2024 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Receptor-interacting serine/threonine-protein kinase 1 | |||
| Name: | Receptor-interacting serine/threonine-protein kinase 1 | ||
| Synonyms: | Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 75926.99 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13546 | ||
| Residue: | 671 | ||
| Sequence: |
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| BDBM647667 | |||
| n/a | |||
| Name | BDBM647667 | ||
| Synonyms: | (5S)-2-(bicyclo[2.1.1]hexan-1-yl)-5- (3,5-difluorophenyl)-2,5,6,7- tetrahydro-3H-pyrrolo[2,1- c][1,2,4]triazol-3-one | US20240025912, Compound 1-4 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H17F2N3O | ||
| Mol. Mass. | 317.3332 | ||
| SMILES | Fc1cc(F)cc(c1)[C@@H]1CCc2nn(c(=O)n12)C12CC(C1)CC2 |r,wU:8.8,(-1.69,3.89,;-2.46,2.55,;-4,2.55,;-4.77,1.22,;-6.31,1.22,;-4,-.11,;-2.46,-.11,;-1.69,1.22,;-1.69,-1.45,;-2.31,-2.86,;-1.17,-3.89,;.16,-3.12,;1.7,-3.28,;2.32,-1.87,;1.18,-.84,;1.34,.69,;-.16,-1.61,;3.83,-1.55,;4.46,-.14,;5.99,-.3,;5.37,-1.55,;6.31,-1.81,;4.97,-2.58,)| | ||
| Structure | 
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