Reaction Details |
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Target | Receptor-interacting serine/threonine-protein kinase 1 |
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Ligand | BDBM647698 |
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Substrate/Competitor | n/a |
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Meas. Tech. | RIPK1-ADP-Glo Enzymatic Assay |
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EC50 | 108±n/a nM |
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Citation | Chen, JL; Chen, Y; DiMauro, EF; Liu, M; Methot, JL; Musacchio, AJ; Palani, A; Pio, B; Duque, LR; Siliphaivanh, P; Vara, BA RIPK1 INHIBITORS AND METHODS OF USE US Patent US20240025912 Publication Date 1/25/2024 |
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More Info.: | Get all data from this article, Assay Method |
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Receptor-interacting serine/threonine-protein kinase 1 |
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Name: | Receptor-interacting serine/threonine-protein kinase 1 |
Synonyms: | Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 75926.99 |
Organism: | Homo sapiens (Human) |
Description: | Q13546 |
Residue: | 671 |
Sequence: | MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL
LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL
EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD
GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC
IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED
VKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFA
PSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPF
AQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLD
PGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQ
IGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKN
CARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRID
LLSSLIYVSQN
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BDBM647698 |
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n/a |
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Name | BDBM647698 |
Synonyms: | (R)-3-(5-(3,5-difluorophenyl)-3-oxo- 5,6-dihydro-3H-[1,2,4]triazolo[3,4- c][1,4]oxazin-2(8H)- yl)bicyclo[1.1.1]pentane-1-carbonitrile | US20240025912, Compound 1-79 |
Type | Small organic molecule |
Emp. Form. | C17H14F2N4O2 |
Mol. Mass. | 344.3155 |
SMILES | Fc1cc(F)cc(c1)[C@@H]1COCc2nn(c(=O)n12)C12CC(C1)(C2)C#N |r| |
Structure |
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