| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK1 [866-1154] |
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| Ligand | BDBM264207 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Inhibition Studies |
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| IC50 | 106±n/a nM |
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| Citation |  Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Compounds and methods for inhibiting JAK US Patent US10167276 Publication Date 1/1/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase JAK1 [866-1154] |
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| Name: | Tyrosine-protein kinase JAK1 [866-1154] |
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| Synonyms: | JAK1 | JAK1 (aa 866-1154) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (aa 866-1154) |
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| Type: | Protein |
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| Mol. Mass.: | 33185.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23458[866-1154] |
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| Residue: | 289 |
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| Sequence: | DPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKE
IEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAV
QICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPV
FWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLV
NTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
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| BDBM264207 |
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| n/a |
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| Name | BDBM264207 |
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| Synonyms: | (2R)-2-(4- ethylpiperidin-1-yl)-N-(3- {2-[(3-methoxy-1- methyl-1H-pyrazol- 4-yl)amino]pyrimidin- 4-yl}-1H-indol- 7-yl)propanamide | US10167276, Example 28 | US10654835, Example 28 | US11247983, Example 28 | US9714236, 28 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H33N9O2 |
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| Mol. Mass. | 503.5993 |
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| SMILES | CCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1 |r| |
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| Structure | 
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