Reaction Details |
| Report a problem with these data |
Target | Tyrosine-protein kinase JAK1 [866-1154] |
---|
Ligand | BDBM313401 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Enzyme Inhibition Studies |
---|
IC50 | <5.00±n/a nM |
---|
Citation | Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Compounds and methods for inhibiting JAK US Patent US10167276 Publication Date 1/1/2019 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Tyrosine-protein kinase JAK1 [866-1154] |
---|
Name: | Tyrosine-protein kinase JAK1 [866-1154] |
Synonyms: | JAK1 | JAK1 (aa 866-1154) | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 | Tyrosine-protein kinase JAK1 (aa 866-1154) |
Type: | Protein |
Mol. Mass.: | 33185.74 |
Organism: | Homo sapiens (Human) |
Description: | P23458[866-1154] |
Residue: | 289 |
Sequence: | DPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKE
IEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAV
QICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPV
FWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLV
NTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
|
|
|
BDBM313401 |
---|
n/a |
---|
Name | BDBM313401 |
Synonyms: | (2R)-N-(3-{2-[(3-ethoxy-1-methyl-1H- pyrazol-4-yl)amino]-5- methylpyrimidin-4-yl}-1H-indol-7-yl)- 3-methoxy-2-(4-methylpiperazin-1- yl)propanamide | US10167276, Example 64 | US10654835, Example 64 | US11247983, Example 64 |
Type | Small organic molecule |
Emp. Form. | C28H37N9O3 |
Mol. Mass. | 547.6519 |
SMILES | CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](COC)N3CCN(C)CC3)cccc12 |r| |
Structure |
|