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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 | ||
| Ligand | BDBM335511 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzyme Assay | ||
| IC50 | <10±n/a nM | ||
| Citation |  Zhou, J; Qiao, L; Weng, L Process for the synthesis of a phosphoinositide 3-kinase inhibitor US Patent US9732097 Publication Date 8/15/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 | |||
| Name: | Tyrosine-protein kinase JAK1 | ||
| Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 133293.73 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458 | ||
| Residue: | 1154 | ||
| Sequence: |
| ||
| BDBM335511 | |||
| n/a | |||
| Name | BDBM335511 | ||
| Synonyms: | US9732097, Example 20 | {1-(cis-4-{[4-(1- hydroxy-1- methylethyl)-6- (trifluoromethyl) pyridin-2- yl]oxy}cyclohexyl)-3- [4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-1H- pyrazol-1-yl]azetidin- 3-yl}acetonitrile | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H31F3N9O2 | ||
| Mol. Mass. | 582.6 | ||
| SMILES | CC(C)(O)c1cc(O[C@H]2CC[C@H](CC2)N2C[N](CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)nc(c1)C(F)(F)F |r,wU:11.14,8.7,(8.63,2.85,;7.3,3.62,;7.3,5.16,;8.63,4.39,;5.96,2.85,;4.87,3.94,;3.39,3.54,;2.3,4.63,;.81,4.23,;.41,2.75,;-1.08,2.35,;-2.17,3.44,;-1.77,4.92,;-.28,5.32,;-3.65,3.04,;-4.99,3.81,;-5.76,2.48,;-7.24,2.87,;-7.64,4.36,;-8.04,5.85,;-4.42,1.71,;-6.53,1.14,;-6.05,-.32,;-7.3,-1.23,;-8.54,-.32,;-8.07,1.14,;-7.3,-2.77,;-8.63,-3.54,;-8.63,-5.08,;-7.3,-5.85,;-5.96,-5.08,;-4.5,-5.55,;-3.59,-4.31,;-4.5,-3.06,;-5.96,-3.54,;2.99,2.06,;4.08,.97,;5.56,1.37,;3.68,-.52,;2.19,-.92,;4.77,-1.61,;3.28,-2.01,)| | ||
| Structure | 
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