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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Interleukin-1 receptor-associated kinase 4 | ||
| Ligand | BDBM348003 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Assay | ||
| IC50 | 550±n/a nM | ||
| Citation |  Jorand-Lebrun, C; Jones, R; Won, AC; Nguyen, N; Johnson, TL; Deselm, LC; Panda, K Heteroaryl compounds as IRAK inhibitors and uses thereof US Patent US9790221 Publication Date 10/17/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Interleukin-1 receptor-associated kinase 4 | |||
| Name: | Interleukin-1 receptor-associated kinase 4 | ||
| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 | ||
| Type: | Protein | ||
| Mol. Mass.: | 51519.08 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9NWZ3 | ||
| Residue: | 460 | ||
| Sequence: |
| ||
| BDBM348003 | |||
| n/a | |||
| Name | BDBM348003 | ||
| Synonyms: | US9790221, Compound 211 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H28N8O | ||
| Mol. Mass. | 456.5428 | ||
| SMILES | CC(=O)NC[C@H]1C[C@H](C1)Nc1nc(ncc1-c1cnn(C)c1)-c1cccc(c1)-c1cnn(C)c1 |r,wU:7.9,5.4,(6.28,-.4,;4.95,.38,;4.95,1.92,;3.61,-.39,;2.28,.38,;.94,-.39,;.54,-1.87,;-.94,-1.47,;-.54,.02,;-2.28,-2.24,;-3.61,-1.46,;-3.61,.08,;-4.94,.85,;-6.28,.08,;-6.28,-1.46,;-4.95,-2.23,;-4.95,-3.77,;-6.2,-4.67,;-5.73,-6.14,;-4.19,-6.14,;-3.42,-7.48,;-3.71,-4.68,;-4.94,2.39,;-6.27,3.16,;-6.26,4.7,;-4.93,5.47,;-3.6,4.7,;-3.6,3.16,;-2.26,5.46,;-2.26,7,;-.79,7.48,;.11,6.23,;1.6,5.83,;-.8,4.98,)| | ||
| Structure | 
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