Reaction Details |
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Target | Aldo-keto reductase family 1 member B1 |
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Ligand | BDBM16445 |
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Substrate/Competitor | BDBM16443 |
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Meas. Tech. | In Vitro Aldose Reductase Inhibition Assay |
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pH | 7±n/a |
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Temperature | 297.15±n/a K |
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IC50 | 210±n/a nM |
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Citation | Mylari, BL; Armento, SJ; Beebe, DA; Conn, EL; Coutcher, JB; Dina, MS; O'Gorman, MT; Linhares, MC; Martin, WH; Oates, PJ; Tess, DA; Withbroe, GJ; Zembrowski, WJ A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners. J Med Chem48:6326-39 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Aldo-keto reductase family 1 member B1 |
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Name: | Aldo-keto reductase family 1 member B1 |
Synonyms: | AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR) |
Type: | Protein |
Mol. Mass.: | 35855.50 |
Organism: | Homo sapiens (Human) |
Description: | P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0 |
Residue: | 316 |
Sequence: | MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF
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BDBM16445 |
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BDBM16443 |
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Name | BDBM16445 |
Synonyms: | 6-[(2-bromobenzene)sulfonyl]-2,3-dihydropyridazin-3-one | 6-phenylsulfonylpyridazin-2H-3-one, 7 | Phenyl-Substituted Sulfonylpyridazinone, 8a |
Type | Small organic molecule |
Emp. Form. | C10H7BrN2O3S |
Mol. Mass. | 315.143 |
SMILES | Brc1ccccc1S(=O)(=O)c1ccc(=O)[nH]n1 |
Structure |
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