| Reaction Details |
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 | Report a problem with these data |
| Target | ATP-sensitive inward rectifier potassium channel 1 |
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| Ligand | BDBM363475 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Electrophysiology Assay |
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| IC50 | 4.80±n/a nM |
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| Citation |  Pasternak, A; Ding, F; Dong, S; Jiang, J; Tang, H; Gu, X; DeJesus, RK; Frie, J; Fu, Q; Suzuki, T; Pu, Z Inhibitors of the renal outer medullary potassium channel US Patent US9850245 Publication Date 12/26/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| ATP-sensitive inward rectifier potassium channel 1 |
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| Name: | ATP-sensitive inward rectifier potassium channel 1 |
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| Synonyms: | ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44809.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_223460826 |
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| Residue: | 391 |
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| Sequence: | MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQS
RFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTP
CVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILA
KISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGE
TIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGT
VESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLY
NEKDVRARMKRGYDNPNFILSEVNETDDTKM
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| BDBM363475 |
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| n/a |
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| Name | BDBM363475 |
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| Synonyms: | 9-(2-(4-(1H-tetrazol-1- yl)phenyl)-2-hydroxyethyl)-4-(4- methyl-5-oxo-2,5-dihydrofuran- 3-yl)-1-oxa-4,9- diazaspiro[5.5]undecan-5-one (single enantiomer, absolute stereochemistry not established) | US9850245, Example 9A |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26N6O5 |
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| Mol. Mass. | 454.479 |
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| SMILES | CC1=C(COC1=O)N1CCOC2(CCN(CC(O)c3ccc(cc3)-n3cnnn3)CC2)C1=O |t:1| |
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| Structure | 
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