Reaction Details |
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Target | ATP-sensitive inward rectifier potassium channel 1 |
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Ligand | BDBM363479 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Electrophysiology Assay |
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IC50 | 100.0±n/a nM |
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Citation | Pasternak, A; Ding, F; Dong, S; Jiang, J; Tang, H; Gu, X; DeJesus, RK; Frie, J; Fu, Q; Suzuki, T; Pu, Z Inhibitors of the renal outer medullary potassium channel US Patent US9850245 Publication Date 12/26/2017 |
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More Info.: | Get all data from this article, Assay Method |
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ATP-sensitive inward rectifier potassium channel 1 |
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Name: | ATP-sensitive inward rectifier potassium channel 1 |
Synonyms: | ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 44809.08 |
Organism: | Homo sapiens (Human) |
Description: | gi_223460826 |
Residue: | 391 |
Sequence: | MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQS
RFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTP
CVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILA
KISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGE
TIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGT
VESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLY
NEKDVRARMKRGYDNPNFILSEVNETDDTKM
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BDBM363479 |
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n/a |
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Name | BDBM363479 |
Synonyms: | (S)-4-(9-(2-(6-(1H-tetrazol-1- yl)pyridin-3-yl)-2-hydroxyethyl)- 1-oxa-4,9- diazaspiro[5.5]undecan-4- yl)furan-2(5H)-one | US9850245, Example 19B |
Type | Small organic molecule |
Emp. Form. | C20H25N7O4 |
Mol. Mass. | 427.457 |
SMILES | O[C@H](CN1CCC2(CC1)CN(CCO2)C1=CC(=O)OC1)c1ccc(nc1)-n1cnnn1 |r,t:16| |
Structure |
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