| Reaction Details |
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 | Report a problem with these data |
| Target | Mast/stem cell growth factor receptor Kit [D816V] |
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| Ligand | BDBM369376 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Cell-Based Assays of c-Kit Mutant Kinase Activity |
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| Ki | 500±n/a nM |
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| Citation |  Lin, J; Buell, J; Chan, K; Ewing, T; Ibrahim, P; Nespi, M; Pham, P; Shi, S; Spevak, W; Wu, G; Zhang, J; Zhang, Y Compounds and methods for kinase modulation, and indications therefor US Patent US10227357 Publication Date 3/12/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mast/stem cell growth factor receptor Kit [D816V] |
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| Name: | Mast/stem cell growth factor receptor Kit [D816V] |
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| Synonyms: | KIT | KIT_HUMAN | Mast/stem cell growth factor receptor Kit (D816V) | Mast/stem cell growth factor receptor Kit 1 (D816V) | SCFR | Tyrosine-protein kinase Kit (Kit)(D816V) |
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| Type: | Protein |
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| Mol. Mass.: | 109854.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human Kit D816V mutant |
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| Residue: | 976 |
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| Sequence: | MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTD
PGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLV
DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYH
RLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS
SVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSAN
VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWE
DYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR
LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS
SAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIV
MILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAF
GKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC
TIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNE
YMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGM
AFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPES
IFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMY
DIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSV
GSTASSSQPLLVHDDV
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| BDBM369376 |
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| n/a |
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| Name | BDBM369376 |
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| Synonyms: | (2R)-4-[6-(4-cyanophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]-N-[(1S)-1-(3- fluorophenyl)ethyl]-2-methyl-piperazine- 1-carboxamide | US10227357, Compound P-0693 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H26FN7O |
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| Mol. Mass. | 483.54 |
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| SMILES | C[C@H](NC(=O)N1CCN(C[C@H]1C)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C#N)c1cccc(F)c1 |r| |
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| Structure | 
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